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Rebeprazole sodium

Rebeprazole sodium Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Rebeprazole sodium
CAS:117976-90-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: Product Name:117976-90-6
CAS:117976-90-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Email: Sales@pipitech.com
Products Intro: Product Name:Rabeprazole Sodium
CAS:117976-90-6
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:Sodium 2-[(RS)-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl]sulfinyl]benzimidazol-1-ide
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
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Products Intro: Product Name:Rebeprazole sodium
CAS:117976-90-6
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
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Products Intro: Product Name:Rebeprazole sodium 117976-90-6
CAS:117976-90-6
Purity:99% Package:1KG;30USD

Lastest Price from Rebeprazole sodium manufacturers

  • Rebeprazole sodium
  • US $1.00 / kg
  • 2019-07-06
  • CAS:117976-90-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
Rebeprazole sodium Basic information
Anti-ulcer drug Uses
Product Name:Rebeprazole sodium
Synonyms:Rabeprazole for system suitability;Aciphex Sodium;Habeprazole Sodium;LY307640 sodium;2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT;2-[[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL]SULFINY]-1H-BENZIMIDAZOLE SODIUM SALT;rebeprazole sodium;sodium 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]benzoimidazole
CAS:117976-90-6
MF:C18H20N3NaO3S
MW:381.42
EINECS:629-730-3
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Rabeprazole
Mol File:117976-90-6.mol
Rebeprazole sodium Structure
Rebeprazole sodium Chemical Properties
Melting point 140-141°C dec.
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility H2O: soluble10mg/mL (clear solution)
form powder
color white to beige
Merck 14,8089
InChIKeyKRCQSTCYZUOBHN-UHFFFAOYSA-N
Safety Information
WGK Germany 3
HS Code 2933399090
MSDS Information
Rebeprazole sodium Usage And Synthesis
Anti-ulcer drugRabeprazole sodium is a anti-ulcer disease drug belonging to proton pump inhibitor and is the sodium salt form of Rabeprazole. The Japanese company Eisai had successfully developed it for the first time with the trade name being “Bolite”. The function of the proton pump inhibitors is reducing the gastric acid secretion so that the lesion site can be stable in order to achieving the effect of curing gastric and duodenal ulcers and stomach-esophageal reflux disease. Clinically it is majorly used for the treatment of acid-related diseases such as stomach and duodenal ulcers, peptic ulcer, gastroesophageal reflux disease and zollinger-ellison syndrome. Rabeprazole is a kind of benzimidazole-substituted compounds. It inhibits the secretion of gastric acid through forming bond with the cytoplasmic proton pump in the gastric cavity wall. This product can specifically inhibit the effect of the adenosine triphosphatase that is the key enzyme during the production of stomach acid. It has inhibitory effect on both basal gastric acid and the gastric acid secretion caused by the stimulation.
Rabeprazole is white-yellowish-white powder with no odor and a molecular weight being 381.43. This product is highly soluble in water or methanol, also soluble in ethanol or ethyl acetate but almost insoluble in ether or ethane. This product does not exhibit optical activity, has hygroscopic effect. Its melting point is 225 ℃ and its partition coefficient at water/octane system of pH 7.0 is about 214. This product is light yellow film-coated tablets (enteric-coated tablets).
Adverse reactions and precautions: gastric cancer should be excluded after use of the drug. Adverse reactions include allergic reactions, palpitations, constipation, diarrhea, headache, edema, leukopenia, AST, ALT, total bilirubin and proteinuria. The combination of Rabeprazole sodium and digoxin can cause increased digoxin concentration. It can’t be taken simultaneously with antacids. Patients of history of drug allergy, cirrhosis, the elderly, pregnant and lactating women, children should take with caution.
The above information is edited by the chemicalbook of Dai Xiongfeng.
UsesIt belongs to national second-class drug that can be used for the treatment of gastric ulcer. It can be used for the treatment of peptic ulcer, gastroesophageal reflux disease, zollinger-ellison syndrome and other diseases.
DescriptionRebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric and duodenal ulcers. From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton after successive condensations. Rabeprazole, a structural analog of Omeprazole, the first compound to have been marketed in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ; a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml.
Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and 20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory conditions including Zollinger-Ellison syndrome.
Chemical PropertiesRebeprazole sodium is White Crystalline Solid
OriginatorEisai (Japan)
Usesanthelminthic, antiseptic, expectorant
Usesantibacterial and antifungal agent effective against gram-positive and gram-negative bacteria, yeast and fungi
UsesRebeprazole sodium is a partially reversible gastric proton pump inhibitor
Brand nameAciphex (Eisai Medical Research) .
General DescriptionRabeprazole sodium, 2[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole sodium salt (Aciphex), is a white toslightly yellowish white solid. It is very soluble in water andmethanol, freely soluble in ethanol, chloroform, and ethyl acetate,and insoluble in ether and hexane. Rabeprazole is aweak base (pyridine N, pKa 4.53) and a weak acid (benzimidazoleN-H, pKa 0.62), faciliting sodium salt formation.
Rabeprazole sodium is formulated as enteric-coated,delayed-release tablets to allow the drug to pass throughthe stomach relatively intact. After oral administration of20-mg peak plasma concentrations (Cmax) occur over arange of 2 to 5 hours (Tmax). Absolute bioavailability for a20-mg oral tablet of rabeprazole (vs. IV administration) isapproximately 52%. The plasma half-life ofrabeprazole ranges from 1 to 2 hours. The effects of foodon the absorption of rabeprazole have not been evaluated.Rabeprazole is 96% bound to human plasma proteins.Rabeprazole is extensively metabolized in the liver. Thethioether and sulfone are the primary metabolites measuredin human plasma resulting from CYP3A oxidation.Additionally, desmethyl rabeprazole is formed via the actionof CYP2C19. Approximately 90% of the drug is eliminatedin the urine, primarily as thioether carboxylic acidand its glucuronide and mercapturic acid metabolites. Theremainder of the dose is recovered in the feces. No unchangedrabeprazole is excreted in the urine or feces.
Rebeprazole sodium Preparation Products And Raw materials
Tag:Rebeprazole sodium(117976-90-6) Related Product Information
Rabeprazole intermediates 2-Hydroxymethyl-3-methyl-4-(3-methoxy propanoxyl)pyridine 2-Hydroxybenzimidazole 4-Nitro-2,3-lutidine-N-oxide (S)-Rabeprazole Sodium Salt Pantoprazole Omeprazole Rabeprazole IMIDAZOLE SODIUM DERIVATIVE 2-[(4-METHOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE Rebeprazole sodium 1-Propanol, 3-[[2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-3-methyl-4-pyridinyl]oxy]- Pyridine Sodium Rabeprazole Enteric-coated Tablet Timoprazole 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 2-[(4-ETHOXY-3-METHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE