- L-Isovaline
-
- $100.00 / 1KG
-
2025-08-08
- CAS:595-40-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000KG
- L-Isovaline
-
- $10.00 / 1KG
-
2025-06-24
- CAS:595-40-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- L-Isovaline
-
- $1.00 / 1kg
-
2019-07-06
- CAS:595-40-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 100KG
|
| | L-Isovaline Basic information |
| | L-Isovaline Chemical Properties |
| Melting point | 289.39°C (estimate) | | Boiling point | 213.6±23.0 °C(Predicted) | | alpha | D25 +11.13° (c = 5 in H2O) | | density | 1.2000 (estimate) | | refractive index | 1.4650 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.38±0.10(Predicted) | | form | Fine Crystalline Powder | | color | White | | Optical Rotation | Consistent with structure | | InChI | InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)/t5-/m1/s1 | | InChIKey | GCHPUFAZSONQIV-RXMQYKEDSA-N | | SMILES | C(O)(=O)[C@](CC)(C)N | | CAS DataBase Reference | 595-40-4(CAS DataBase Reference) |
| Safety Statements | 24/25 | | TSCA | No |
| Provider | Language |
|
ACROS
| English |
| | L-Isovaline Usage And Synthesis |
| Uses | a-Me-Gly(Ethyl)-OH is used in preparation of peptide compound comprising highly sterically hindered amino acid via reaction of electron-withdrawing group-protected N-unsubstituted-α,α-disubstituted amino acid with peptide followed by N-alkylation. | | Synthesis | 1.4) Compound F1 (13.8 g, 95.0 mmol) and sodium hydroxide (7.6 g, 190.08 mmol) were added sequentially to a mixture of ethanol (200 mL) and water (1:1 by volume) and heated to reflux for 4 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with 2 M hydrochloric acid solution, followed by evaporation of the solvent. The residue was dissolved in a small amount of water and purified by strongly acidic cation exchange resin 732. The final product G1 (10 g, 90% yield) was obtained as a white solid. | | Purification Methods | Crystallise it from aqueous Me2CO, or better by dissolving in H2O and adding excess Me2CO. [Baker et al. J Am Chem Soc 74 4701 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2573-2577 1961.] | | References | [1] Patent: CN108440320, 2018, A. Location in patent: Paragraph 0033; 0035; 0043 |
| | L-Isovaline Preparation Products And Raw materials |
|