- C8 CERAMIDE
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- $1.00 / 1KG
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2019-12-23
- CAS:74713-59-0
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | C8 CERAMIDE Basic information |
| | C8 CERAMIDE Chemical Properties |
| Melting point | 68-70°C | | Boiling point | 541.37°C (rough estimate) | | density | 0.9974 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | −20°C | | solubility | DMSO or ethanol: soluble | | form | waxy solid | | color | White | | Stability: | Temperature Sensitive | | CAS DataBase Reference | 74713-59-0(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29225000 |
| | C8 CERAMIDE Usage And Synthesis |
| Description | C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4 | | Chemical Properties | Off White Powder | | Uses | A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis | | Uses | C-8 Ceramide is a ceramide analog. | | Definition | ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid. | | References | 1) Mathias?et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA,?88?109
2) Jarvis?et al. (1993)?Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA?91?73
3) Upham?et al. (2003),?Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett.,?191?27
4) Nakajima?et al. (2002),?Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem.,?80?697 |
| | C8 CERAMIDE Preparation Products And Raw materials |
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