- SPDP
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- $31.00 / 200mg
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2026-04-22
- CAS:68181-17-9
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
- SPDP-NHS ester
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- $0.00 / 10g
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2025-06-07
- CAS:68181-17-9
- Min. Order: 10g
- Purity: >99.00%
- Supply Ability: 10g
- SPDP
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- $1.00 / 1KG
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2019-07-11
- CAS:68181-17-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 25kg
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| Melting point | 84-86 °C(lit.) | | Boiling point | 465.9±55.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | acetone: 50 mg/mL | | form | powder | | pka | 1.76±0.19(Predicted) | | color | White to Light Yellow | | BRN | 1548137 | | Stability: | Hygroscopic, Moisture Sensitive | | InChI | InChI=1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2 | | InChIKey | JWDFQMWEFLOOED-UHFFFAOYSA-N | | SMILES | C(ON1C(=O)CCC1=O)(=O)CCSSC1=NC=CC=C1 | | CAS DataBase Reference | 68181-17-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 1-10 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids |
| Description | SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells. | | Chemical Properties | White Solid | | Uses | Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds. | | Uses | A heterobifunctional cross-linker | | Uses | 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker. | | General Description | 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker. | | reaction suitability | reagent type: cross-linking reagent |
| | SPDP Preparation Products And Raw materials |
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