|
|
| | (-)-BETA-HYDRASTINE Basic information |
| Product Name: | (-)-BETA-HYDRASTINE | | Synonyms: | HYDRASTINE, (-)-B-(P) (AHP Verified);HYDRASTINE, (-)-B-(P);Hydrastine (base and/or unspecified salts);(1R,9S)-(-)-β-Hydrastine;(3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one;[R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one;(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone;[S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one | | CAS: | 118-08-1 | | MF: | C21H21NO6 | | MW: | 383.39 | | EINECS: | 204-233-0 | | Product Categories: | XYLOCAINE;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 118-08-1.mol |  |
| | (-)-BETA-HYDRASTINE Chemical Properties |
| Melting point | 132℃ | | alpha | D20 -50° (c = 0.3 in abs alc) | | Boiling point | 510.32°C (rough estimate) | | density | 1.339±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.5614 (estimate) | | storage temp. | −20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | 7.8(at 25℃) | | Water Solubility | 30mg/L(20 ºC) | | CAS DataBase Reference | 118-08-1(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | 1544 | | WGK Germany | 3 | | RTECS | MU6030000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2939800000 |
| | (-)-BETA-HYDRASTINE Usage And Synthesis |
| Description | (1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores. | | Uses | (-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis. | | Uses | anesthetic (local), antiarrhythmic | | Definition | ChEBI: A natural product found in Hydrastis canadensis. |
| | (-)-BETA-HYDRASTINE Preparation Products And Raw materials |
|