L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺
中文名称 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 |
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中文同义词 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺;化合物DAMGO;受体选择性激动剂DAMGO;78123-71-4(游离);DAMGO,Μ阿片受体激动剂 |
英文名称 | DAGO |
英文同义词 | Tyr-D-Ala-Gly-MePhe-Gly-ol;Tyr-D-Ala-Gly-MePhe-NH-(CH2)2OH;Tyr-D-Ala-Gly-N-methylphenylalanine-glycinol;TYR-D-ALA-GLY-N-ME-PHE-GLY-OL;TYR-D-ALA-GLY-N-METHYL-PHE-GLY-OL;DAMGO;DAGO;(D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN |
CAS号 | 78123-71-4 |
分子式 | C26H35N5O6 |
分子量 | 513.59 |
EINECS号 | |
相关类别 | 目录多肽;Peptide;Opioid receptor and opioid-like receptor |
Mol文件 | 78123-71-4.mol |
结构式 |
L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 性质
沸点 | 922.7±65.0 °C(Predicted) |
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密度 | 1.271±0.06 g/cm3(Predicted) |
储存条件 | -15°C |
溶解度 | 乙醇中≥40.7 mg/mL;水中≥40.7 mg/mL; ≥42.2 mg/mL,溶于 DMSO |
形态 | 固体 |
酸度系数(pKa) | 9.97±0.15(Predicted) |
颜色 | 白色 |
水溶解性 | Soluble in water (4 mM) |
序列 | H-Tyr-D-Ala-Gly-NMe-Phe-Gly-ol |
稳定性 | 吸湿性 |
Kd: 3.46±0.84 nM (native μ-OPR)
DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. In native μ-OPR, the K d value for DAMGO is 3.46± 0.84 nM (n=3). The chimeric receptor MMDD, in which the carboxy-terminal half of μ-OPR is replaced with the corresponding region of δ-OPR, exhibits an equivalent affinity (K d =2.13±0.40 nM; n=3) to DAMGO compared with the native μ-OPR. DAMGO is a selective μ-opioid peptide. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies. Regulation of neuronal response to CXCL12 is essential for shaping of developing and mature central nervous system (CNS). To establish whether DAMGO alter the effect of CXCL12 on neuronal survival, the ability of CXCL12 to protect neurons from N-methyl-d-aspartate (NMDA)-induced death is examined in the presence and absence of DAMGO. Cortical cultures are treated with DAMGO (1 and 10 μM). Neurons are subsequently exposed to NMDA (20 min) and/or CXCL12 (added 10 min before NMDA) in the absence of glia and then returned to the original culture dishes with the glial feeder layer. Neuronal death is evaluated after 24 h. DAMGO inhibits neuronal survival promoted by CXCL12.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P0210 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 DAMGO | 78123-71-4 | 1mg | 600元 |
2024/08/19 | HY-P0210 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 DAMGO | 78123-71-4 | 5mg | 990元 |