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PARAOXON

PARAOXON Basic information
Product Name:PARAOXON
Synonyms:DIETHYL P-NITROPHENYL PHOSPHATE;E 600;ESTER 25;FOSFAKOL;ETICOL;Chinorta;Chinorto;Diaethyl-p-nitrophenylphosphorsaeureester
CAS:311-45-5
MF:C10H14NO6P
MW:275.2
EINECS:206-221-0
Product Categories:Inhibitors;All Inhibitors
Mol File:311-45-5.mol
PARAOXON Structure
PARAOXON Chemical Properties
Melting point 300°C
Boiling point 169-170°C
density 1.274 g/mL at 25 °C(lit.)
refractive index n20/D 1.51(lit.)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form oil
color yellow
Odorslt odor
Water Solubility 3.627g/L(20 ºC)
Merck 13,7102
BRN 1915526
Stability:Moisture Sensitive
CAS DataBase Reference311-45-5
EPA Substance Registry SystemParaoxon (311-45-5)
Safety Information
Hazard Codes T+,N
Risk Statements 26/27/28-50
Safety Statements 36/37/39-45-61
RIDADR UN 2810 6.1/PG 1
WGK Germany 3
RTECS TC2275000
HazardClass 6.1(a)
PackingGroup I
Hazardous Substances Data311-45-5(Hazardous Substances Data)
ToxicityLD50 orally in rats: 1.8 mg/kg (Pickering, Malone)
MSDS Information
ProviderLanguage
SigmaAldrich English
PARAOXON Usage And Synthesis
Chemical PropertiesOily Liquid
Chemical PropertiesParaoxon is an odorless, reddish-yellow oil. Fruity odor.
UsesA cholinesterase inhibitor
UsesParaoxon-ethyl has been used as a substrate?in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein?L3 (HDL3)?to?HDL2?in vivo.
UsesInsecticide.
DefinitionChEBI: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.
Synthesis Reference(s)Tetrahedron Letters, 31, p. 3359, 1990 DOI: 10.1016/S0040-4039(00)89065-6
General DescriptionReddish-yellow oily liquid with a faint fruity odor.
Reactivity ProfileOrganophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Fire HazardFlash point data for PARAOXON are not available; however, PARAOXON is probably combustible.
Biochem/physiol ActionsPotent irreversible acetylcholinesterase inhibitor
Safety ProfileA deadly poison by ingestion,intraperitoneal, intravenous, subcutaneous, intramuscular,and parenteral routes. Mutation data reported. Humansystemic effects: coma, convulsions, miosis. Acholinesterase inhibitor. An insecticide. When heated todecompos
Potential ExposureAn organophosphate insecticide. Has been used as a medication.
ShippingUN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
IncompatibilitiesKeep away from alkaline materials and strong oxidizers. Contact with oxidizers can cause the release of toxic oxides of phosphorus. May react violently with antimony(V) pentafluoride. Incompatible with lead diacetate, magnesium, silver nitrate. In the presence of strong reducing agents such as hydrides, organophosphates form highly toxic and flammable phosphine gas.
Waste DisposalIn accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
PARAOXON Preparation Products And Raw materials
Raw materials4-Nitrophenol-->Diethyl phosphite
Preparation ProductsDisodium 4-nitrophenylphosphate
Tag:PARAOXON(311-45-5) Related Product Information
Trimethyl phosphite DIMETHYL PHOSPHATE Diethyl phosphite DIETHYL PHOSPHATE PHENYLPHOSPHORIC ACID 4-Nitrosophenol METHYL PARAOXON,PARAOXON-METHYL,Dimethyl paraoxon,PARAOXON-METHYL PESTANAL, > 96%,O,O-Dimethyl O-(4-nitrophenyl) phosphate, Paraoxon-methyl TRI-AMMONIUM PHOSPHATE TRIHYDRATE Dimethyl phosphite PARAOXON Trimethyl phosphate Parathion 4-(4-NITROPHENYL)MORPHOLINE ETHYLPHOSPHONIC ACID 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester DIETHYLMETHYLPHOSPHATE DIMETHYLETHYLPHOSPHATE Bis(3-chloropropyl) p-nitrophenyl phosphate