Dihydromunduletone manufacturers
- Dihydromunduletone
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- $311.00 / 1mg
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2025-09-29
- CAS:674786-20-0
- Min. Order:
- Purity: 99.96%
- Supply Ability: 10g
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| | Dihydromunduletone Basic information |
| Product Name: | Dihydromunduletone | | Synonyms: | Dihydromunduletone;Ethanone, 1-(3,4-dihydro-3,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-;Dihydromunduletone, 10 mM in DMSO | | CAS: | 674786-20-0 | | MF: | C25H28O6 | | MW: | 424.49 | | EINECS: | | | Product Categories: | | | Mol File: | 674786-20-0.mol |  |
| | Dihydromunduletone Chemical Properties |
| Boiling point | 615.9±55.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (588.94 mM) | | form | Solid | | pka | 7.70±0.60(Predicted) | | color | Light yellow to yellow |
| | Dihydromunduletone Usage And Synthesis |
| Description | Dihydromunduletone (DHM), a rotenoid derivative, was validated using cell-free aGPCR/heterotrimeric G protein guanosine 5′-3-O-(thio)triphosphate binding reconstitution assays. DHM inhibited GPR56 and GPR114/ADGRG5, which have similar tethered agonists, but not the aGPCR GPR110/ADGRF1, M3 muscarinic acetylcholine, or β2 adrenergic GPCRs. DHM inhibited tethered peptide agonist-stimulated and synthetic peptide agonist-stimulated GPR56 but did not inhibit basal activity, demonstrating that it antagonizes the peptide agonist. DHM is a novel aGPCR antagonist and potentially useful chemical probe that may be developed as a future aGPCR therapeutic. | | Uses | Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1]. | | Definition | ChEBI: 1-(3,7-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-2-(5-methoxy-2,2-dimethyl-1-benzopyran-6-yl)ethanone is a stilbenoid. | | References | [1] HANNAH M STOVEKEN. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.[J]. Molecular Pharmacology, 2016, 90 3: 214-224. DOI:10.1124/mol.116.104828. |
| | Dihydromunduletone Preparation Products And Raw materials |
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