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Morphothiadin

Morphothiadin Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Morphothiadin
CAS:1092970-12-1
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:Morphothiadin
CAS:1092970-12-1
Purity:99.88% Package:1mg;97USD|5mg;297USD|10mg;474USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:Morphothiadin
CAS:1092970-12-1
Purity:85.0-99.8% Package:1KG;1USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:GLS4
CAS:1092970-12-1
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:Morphothiadin
CAS:1092970-12-1
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

Morphothiadin manufacturers

  • Morphothiadin
  • Morphothiadin pictures
  • $97.00 / 1mg
  • 2024-11-19
  • CAS:1092970-12-1
  • Min. Order:
  • Purity: 99.88%
  • Supply Ability: 10g
  • Morphothiadin
  • Morphothiadin pictures
  • $97.00 / 1mg
  • 2024-11-19
  • CAS:1092970-12-1
  • Min. Order:
  • Purity: 99.88%
  • Supply Ability: 10g
  • Morphothiadin USP/EP/BP
  • Morphothiadin USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-22
  • CAS:1092970-12-1
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
Morphothiadin Basic information
Product Name:Morphothiadin
Synonyms:Morphothiadin;GLS4 (GLS 4;5-Pyrimidinecarboxylic acid, 4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-, ethyl ester;Morphothiadin USP/EP/BP;GLS 4(Morphothiadin);Morphothiadin (GLS4);Morphothiadin,inhibit,HBV,Inhibitor,GLS-4,GLS 4,Hepatitis B virus;Ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
CAS:1092970-12-1
MF:C21H22BrFN4O3S
MW:509.39
EINECS:
Product Categories:
Mol File:1092970-12-1.mol
Morphothiadin Structure
Morphothiadin Chemical Properties
Boiling point 577.2±60.0 °C(Predicted)
density 1.58±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 12 mg/ml; DMSO: 1 mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.3 mg/ml
form A solid
pka8.38±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Morphothiadin Usage And Synthesis
UsesMorphothiadin, is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM. It strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02).
in vivo

The area under the concentration-time curve from 0 to 24 h (AUC0-24) of Morphothiadin (GLS4) is 556 h ng/mL. After intravenous administration of 10 mg/kg Morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. The bioavailability of Morphothiadin is 25.5%. It is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment[2].

Morphothiadin Preparation Products And Raw materials
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