| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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| Tel: |
020-13556033878 2965585218 13556033878 |
| Email: |
chemcell@hotmail.com |
| Products Intro: |
Product Name:LDH-IN-1
CAS:1964515-43-2
Purity:98% Package:5mg;10mg;50mg;100mg,1g;5g;10g;50g;100g
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LDH-IN-1 manufacturers
- LDH-IN-1
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- $198.00 / 1mg
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2025-11-11
- CAS:1964515-43-2
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
- LDH-IN-1
-
- $198.00 / 1mg
-
2025-11-10
- CAS:1964515-43-2
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
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| | LDH-IN-1 Basic information |
| Product Name: | LDH-IN-1 | | Synonyms: | LDH-IN-1;LDH inhibitor 1;4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)phenyl]methyl]-3-[1,1'-biphenyl]-3-yl-5-(cyclopropylmethyl)-1H-pyrazol-1-yl]-;Lactate Dehydrogenase,inhibit,LDH,LDH IN 1,Inhibitor,LDHIN1;2-(3-([1,1'-Biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid;LDH-IN-1, 10 mM in DMSO;2-(3-([1,1'-Biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid | | CAS: | 1964515-43-2 | | MF: | C30H26N4O4S2 | | MW: | 570.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1964515-43-2.mol |  |
| | LDH-IN-1 Chemical Properties |
| Boiling point | 837.5±75.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 52 mg/mL (91.12 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 3.19±0.10(Predicted) | | color | White to off-white |
| | LDH-IN-1 Usage And Synthesis |
| Uses | LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. | | in vivo | LDH-IN-1 shows clearance values that far exceed hepatic blood flow (HBF) in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg[1]. | | References | [1] Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204. DOI:10.1021/acs.jmedchem.7b00941 |
| | LDH-IN-1 Preparation Products And Raw materials |
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