党参炔苷
| 中文名称 | 党参炔苷 |
|---|---|
| 中文同义词 | |
| 英文名称 | Lobetyolin |
| 英文同义词 | β-D-Glucopyranoside, (1R,2R,7E)-2-hydroxy-1-[(1E)-5-hydroxy-1-pentenyl]-7-nonene-3,5-diynyl (9CI) |
| CAS号 | 129277-38-9 |
| 分子式 | C20H28O8 |
| 分子量 | 396.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 129277-38-9.mol |
| 结构式 |  |
党参炔苷 性质
| 沸点 | 698.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 11.39±0.20(Predicted) |
Lobetyolin 是一种分离自 Codonopsis pilosula 的生物活性化合物。Lobetyolin 具有抗炎，抗氧化和黄嘌呤氧化酶抑制活性。Lobetyolin 还通过抑制 ASCT2 介导的谷氨酰胺代谢来诱导细胞凋亡。
Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively.