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2H-Cho-Arg (trifluoroacetate salt)

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
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Products Intro: Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
Company Name: Changzhou Ruikaijia polymer material Technology Co., LTD  
Tel: 3693241975
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Products Intro: CAS:1609010-59-4
Purity:98% Package:5g；10g；20g；100g；100kg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Products Intro: Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:95% Package:1mg;5mg;10mg
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology  
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Products Intro: Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:95%+ Package:1g;5g;10g;25g;50g;100g;
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Products Intro: Product Name:2H-Cho-Arg (trifluoroacetate salt)
CAS:1609010-59-4
Purity:详情请点击官网 Package:1 mg
2H-Cho-Arg (trifluoroacetate salt) Basic information
Product Name:2H-Cho-Arg (trifluoroacetate salt)
Synonyms:2H-Cho-Arg (trifluoroacetate salt);(3β)-[6-[[(2S)-2-amino-(5α)-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate],cholestan-3-ol,bis(2,2,2-trifluoroacetate)
CAS:1609010-59-4
MF:C41H72F3N5O5
MW:772.05
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Mol File:1609010-59-4.mol
2H-Cho-Arg (trifluoroacetate salt) Structure
2H-Cho-Arg (trifluoroacetate salt) Chemical Properties
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
Safety Information
MSDS Information
2H-Cho-Arg (trifluoroacetate salt) Usage And Synthesis
Description2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.1 It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).
References1. Sheng, R., Wang, Z., Luo, T., et al. Skeleton-controlled pDNA delivery of renewable steroid-based cationic lipids, the endocytosis pathway analysis and intracellular localization Int. J. Mol. Sci. 19(2),(2018).
2H-Cho-Arg (trifluoroacetate salt) Preparation Products And Raw materials
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