PubChem ID: 397887 manufacturers
- LMP744 hydrochloride
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- $122.00 / 1mg
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2025-05-02
- CAS:308246-57-3
- Min. Order:
- Purity: 98.44%
- Supply Ability: 10g
- LMP744 hydrochloride
-
- $122.00 / 1mg
-
2025-04-28
- CAS:308246-57-3
- Min. Order:
- Purity: 98.44%
- Supply Ability: 10g
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| | PubChem ID: 397887 Basic information |
| Product Name: | PubChem ID: 397887 | | Synonyms: | PubChem ID: 397887;LMP744 hydrochloride;LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride;NSC706744 hydrochloride);LMP744; LMP-744; LMP 744; MJ-III-65; NSC-706744;Mj-III-65;MJ-III65 hydrochloride;LMP744 HCl | | CAS: | 308246-57-3 | | MF: | C24H25ClN2O7 | | MW: | 488.92 | | EINECS: | | | Product Categories: | | | Mol File: | 308246-57-3.mol |  |
| | PubChem ID: 397887 Chemical Properties |
| Melting point | 284-288 °C | | storage temp. | Store at -20°C | | solubility | DMSO : 5.56 mg/mL (11.37 mM) | | form | Solid | | color | Light brown to brown |
| | PubChem ID: 397887 Usage And Synthesis |
| Uses | LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1]. | | in vivo | LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. | Animal Model: | Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1]. | | Dosage: | 10, 25, or 50 mg/kg/week, 4 weeks | | Administration: | I.V. push via tail vein | | Result: | Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity. |
| | IC 50 | Top1 | | References | [1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 DOI:10.1124/mol.106.024372 |
| | PubChem ID: 397887 Preparation Products And Raw materials |
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