2BAct(eIF2B activator 2BAct) manufacturers
- 2BAct
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- $53.00 / 1mg
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2024-11-19
- CAS:2143542-28-1
- Min. Order:
- Purity: 98.11%
- Supply Ability: 10g
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| | 2BAct(eIF2B activator 2BAct) Basic information |
| Product Name: | 2BAct(eIF2B activator 2BAct) | | Synonyms: | 2BAct(eIF2B activator 2BAct);2BAct;2-Pyrazinecarboxamide, N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-;N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide;permeable,primary,inhibit,Eukaryotic Initiation Factor (eIF),2BAct,stress,defects,response,fibroblast,neurological,Inhibitor,CNS;2BAct, 10 mM in DMSO | | CAS: | 2143542-28-1 | | MF: | C19H16ClF3N4O3 | | MW: | 440.8 | | EINECS: | | | Product Categories: | | | Mol File: | 2143542-28-1.mol |  |
| | 2BAct(eIF2B activator 2BAct) Chemical Properties |
| Boiling point | 671.6±55.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | solubility | DMSO: soluble | | form | A solid | | pka | 12.16±0.40(Predicted) | | color | Light yellow to light brown |
| | 2BAct(eIF2B activator 2BAct) Usage And Synthesis |
| Uses | 2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1]. | | in vivo | 2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response[1]. | | IC 50 | eIF2 | | References | [1] Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9. DOI:10.7554/eLife.42940 |
| | 2BAct(eIF2B activator 2BAct) Preparation Products And Raw materials |
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