COH-SR4
(Mitochondria uncoupler SR4) manufacturers
- COH-SR4
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- $37.00 / 50mg
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2025-07-15
- CAS:73439-19-7
- Min. Order:
- Purity: 99.67%
- Supply Ability: 10g
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| | COH-SR4
(Mitochondria uncoupler SR4) Basic information |
| Product Name: | COH-SR4
(Mitochondria uncoupler SR4) | | Synonyms: | COH-SR4
(Mitochondria uncoupler SR4);Urea, N,N'-bis(3,5-dichlorophenyl)-;COH-SR4;anticancer,anti-proliferative,kinase,leukemia,protein,breast,cancers,lung,COH SR4,COHSR4,anti-adipogenic,COH-SR-4,Inhibitor,AMPK,melanoma,inhibit,COH-SR4,AMP-activated protein kinase,AMP-activated;COH-SR4, 10 mM in DMSO;AMPK Activator, COH-SR4 | | CAS: | 73439-19-7 | | MF: | C13H8Cl4N2O | | MW: | 350.03 | | EINECS: | | | Product Categories: | | | Mol File: | 73439-19-7.mol |  |
| | COH-SR4
(Mitochondria uncoupler SR4) Chemical Properties |
| Melting point | 298-300 °C | | Boiling point | 363.2±42.0 °C(Predicted) | | density | 1.608±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (357.11 mM; Need ultrasonic) | | form | Solid | | pka | 12.42±0.70(Predicted) | | color | White |
| | COH-SR4
(Mitochondria uncoupler SR4) Usage And Synthesis |
| Uses | N,N'-Bis(3,5-dichlorophenyl)-urea is a by-product during the synthesis of Vinclozolin (V314050), which is an agricultural fungicide. | | Biological Activity | Cell permeable: yes | | in vivo | COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake[2].
COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice[2].
COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice[2].
COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice[2].
| Animal Model: | Nine-week old male C57BL/6J mice[2] | | Dosage: | 5 mg/kg | | Administration: | Oral gavage, three times a week, for 6 weeks | | Result: | Decreased body weight and fat mass in HFD obese mice. |
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| | COH-SR4
(Mitochondria uncoupler SR4) Preparation Products And Raw materials |
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