| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:JH-VIII-49
CAS:2209084-73-9
Package:100mg/RMB 31500
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| | JH-VIII-49 Basic information |
| Product Name: | JH-VIII-49 | | Synonyms: | JH-VIII-49;Androst-5-en-3-amine, 17-(7-isoquinolinyl)-N,N-dimethyl-, (3β,17β)- | | CAS: | 2209084-73-9 | | MF: | C30H40N2 | | MW: | 428.66 | | EINECS: | | | Product Categories: | | | Mol File: | 2209084-73-9.mol |  |
| | JH-VIII-49 Chemical Properties |
| Boiling point | 564.5±50.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | pka | 9.57±0.70(Predicted) |
| | JH-VIII-49 Usage And Synthesis |
| Uses | JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518)[1][2]. | | IC 50 | CDK8: 16 nM (IC50) | | References | [1] Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 |
| | JH-VIII-49 Preparation Products And Raw materials |
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