Propargyl-PEG8-NHS ester manufacturers
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| | Propargyl-PEG8-NHS ester Basic information |
| Product Name: | Propargyl-PEG8-NHS ester | | Synonyms: | Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;Propargyl-PEG7-C2-CONHS ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 2182601-74-5 | | MF: | C24H39NO12 | | MW: | 533.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2182601-74-5.mol |  |
| | Propargyl-PEG8-NHS ester Chemical Properties |
| Boiling point | 593.4±60.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | solubility | Soluble in DCM |
| | Propargyl-PEG8-NHS ester Usage And Synthesis |
| Description | Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment. | | Biological Activity | Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | PEGs | Alkyl/ether | |
| | Propargyl-PEG8-NHS ester Preparation Products And Raw materials |
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