Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:Phenanthriplatin;Phenanthriplatin CAS:1416900-51-0 Purity:98% Package:5 mg
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| Phenanthriplatin Basic information |
| Phenanthriplatin Chemical Properties |
| Phenanthriplatin Usage And Synthesis |
Enzyme inhibitor | This potent Pt(II) complex (FW = 505.82 g/mol; CAS 1416900-51-0), also known as cis-diamminephenanthridinechloroplatinum(II), penetrates cell membranes either by passive diffusion or carrier-mediated active transport, with the hydrophobic ligand maximizing cellular uptake and making it cytotoxic compared with cisplatin and carbinatoplatin. Its molecular structure was designed with based the X-ray structure of RNA polymerase II (Pol II), when stalled at a monofunctional pyriplatin-DNA adduct. Phenanthriplatin interacts with guanine residues, forming highly potent, monofunctional DNA adducts. While many Pol II elongation complexes stall after successful addition of CTP opposite the phenanthriplatin-dG adduct in an error-free manner, a few slowly undergo error-prone bypass of the phenanthriplatin-dG lesion, a behavior that resembles DNA polymerases that similarly switch from high-fidelity replicative DNA processing (errorfree) to low-fidelity translesion DNA synthesis (error-prone) at DNA damage sites |
| Phenanthriplatin Preparation Products And Raw materials |
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