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Suprofen

Suprofen Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:suprofen
CAS:40828-46-4
Purity:0.99 Package:1kg
Company Name: Mainchem Co., Ltd.  
Tel: +86-0592-6210733
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Products Intro: Product Name:Dolasteron
CAS:40828-46-4
Company Name: Sangel Pharmaceutical & Chemical Factory  Gold
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Products Intro: Product Name:Suprofen
CAS:40828-46-4
Purity:99% Package:bag
Company Name: J & K SCIENTIFIC LTD.  
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Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:Suprofen
CAS:40828-46-4
Package:100Mg,10Mg,50Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Suprofen
CAS:40828-46-4
Purity:98%
Suprofen Basic information
Product Name:Suprofen
Synonyms:1H-Indole-3-carboxylic acid(2α,6α,8α,9αβ)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester;Dolasetron Methanesulformte;MDL-73147EF:Anzemet;2-[4-(Thiophene-2-carbonyl)phenyl]propanoic acid;a-Methyl-p-(2-thenoyl)phenylacetic acid;2-[4-(thiophene-2-carbonyl)phenyl]propionic acid;Suprofen (200 mg);α-Methyl-4-(2-thienylcarbonyl)benzeneacetic Acid
CAS:40828-46-4
MF:C14H12O3S
MW:260.30828
EINECS:255-096-9
Product Categories:Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File:40828-46-4.mol
Suprofen Structure
Suprofen Chemical Properties
Melting point 278°C
Boiling point 373.57°C (rough estimate)
density 1.2959 (rough estimate)
refractive index 1.5050 (estimate)
storage temp. -20°C Freezer
pka3.91(at 25℃)
Water Solubility soluble
CAS DataBase Reference40828-46-4(CAS DataBase Reference)
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
HS Code 2934990002
ToxicityLD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers)
Suprofen Usage And Synthesis
DescriptionSuprofen is an arylpropionic acid analgesic/antiinflammatory agent with close structural resemblance to ketoprofen. It is more potent in many assays than indomethacin and ketoprofen and appears better tolerated.
Chemical PropertiesOff-White to Light-Brown
OriginatorJanssen (Belgium)
UsesProstaglandin biosynthesis inhibitor. Analgesic
UsesBridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
DefinitionChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
Brand nameProfenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.
Veterinary Drugs and TreatmentsSuprofen is a non-steroidal anti-inflammatory agent similar to flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids that inhibit the cyclo-oxygenase enzymes responsible for conversion of arachadonic acid from cell membranes into various prostaglandins. These prostaglandins mediate certain aspects of ocular inflammation including disruption of the blood-aqueous barrier, uveal vasodilation, increases in intraocular pressure, and leakage of white blood cells and protein from uveal vessels into the aqueous humor. Prostaglandins cause iris sphincter constriction (miosis) independent of cholinergic mechanisms. Suprofen can inhibit this intraocular miosis and may also be useful in the management of uveal inflammation (usually in addition to topical steroids).
Tag:Suprofen(40828-46-4) Related Product Information
Flurbiprofen suprofen acyl glucuronide (S)-(+)-Suprofen,(S)-Suprofen suprofen-copper(II) complex (R)-Suprofen,R(-)-Suprofen Dearboxy suprofen SUPROFEN USP(CRM STANDARD) Suprofen-D3 4-((5-Bromo-2-thienyl)carbonyl)-alpha-methylbenzeneacetic acid LC-R 505 Cliprofen Suprofen (S)-(+)-2-Phenylpropionic acid Thifensulfuron Propionic acid Cephalothin Tetrahydrothiophene 4-Methoxyphenylacetone