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Ciproxifan

Ciproxifan Suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
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Products Intro: Product Name:Ciproxifan
CAS:184025-18-1
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
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Products Intro: Product Name: Ciproxifan
CAS:184025-18-1
Purity:99% Package:1g;1USD
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:Ciproxifan
CAS:184025-18-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Products Intro: Product Name:FUB359
CAS:184025-18-1
Purity:99% Package:5KG;1KG Remarks:FUB359
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Ciproxifan (FUB-359)
CAS:184025-18-1
Purity:98% Package:2mg Remarks:V1230

Ciproxifan manufacturers

  • Ciproxifan
  • 	Ciproxifan pictures
  • $1.00 / 1g
  • 2019-12-24
  • CAS:184025-18-1
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 20kg
Ciproxifan Basic information
Product Name:Ciproxifan
Synonyms:Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;FUB 359;Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-;Ciproxifan, >=99%;CS-757;Ciproxifan (FUB-359);Methanone, cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-;Ciproxifan USP/EP/BP
CAS:184025-18-1
MF:C16H18N2O2
MW:270.33
EINECS:
Product Categories:Inhibitors
Mol File:184025-18-1.mol
Ciproxifan Structure
Ciproxifan Chemical Properties
Boiling point 526.9±35.0 °C(Predicted)
density 1.231
storage temp. 2-8°C
solubility H2O: insoluble
pka14.54±0.10(Predicted)
form solid
color white
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-43
Safety Statements 26-36/37/39
WGK Germany 3
MSDS Information
Ciproxifan Usage And Synthesis
DefinitionChEBI: Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone is an aromatic ketone.
Biological Activityciproxifan is a novel and potent antagonist of histamine h3-receptor with a ic50 value of 9.2±1.8nm [1].ciproxifan has shown the in-vitro antagonistic action to h3-receptor with a ic50 value of 9.2±1.8nm. in addition, ciproxifan has been reported to competitively antagonize the (r) α-meha induced relaxation of electrically stimulated guinea pig ileum longitudinal muscle. besides, ciproxifan has been revealed to have the effect on [125i]iodoproxyfan binding with a ki value of 0.7±0.2 nm. apart from these, ciproxifan has been found to be a selective antagonist with pki values of 9.3, 4.9, 4.6, 5.5, 5.4, 4.9, <5.0, 4.8, <5.5 and <5.7 for h3, h2, h1, muscarinic m3, adrenergic α1d, β1, serotonin 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4, respectively [1].
in vitroCiproxifan inhibits [3H]HA release from synaptosomes with Ki of 0.5 nM. It inhibits the binding of [125I]iodoproxyfan at the brain H3 receptor with Ki of 0.7 nM. It displays high affinity at H3 receptor but shows low apparent affinity at other receptor subtypes as evaluated in functional tests on isolated organs ( histamine H1 and H2, muscarinic M3, adrenergic α1D and β1, serotonin 5-HT1B, 5-HT2A, 5-HT3 and 5-HT4 >).
in vivoCiproxifan intravenously injected at dose of 1 mg/kg decreases the H3-receptor ligand concentration in serum in Male Swiss mice, with half-times of distribution phase of 13 min and elimination phase of 87 min, respectively. Ciproxifan (1 mg/kg, po) rises brain t-MeHA level rapidly in Male Swiss mice, being already significantly increased after 30 min, reaching a plateau between 90 and 180 min and still remaining enhanced after 270 min. It leads to ED50 values of 0.23 mg/kg in cerebral cortex, 0.28 mg/kg in striatum and 0.30 mg/kg in hypothalamus in Male Wistar rats. It (3 mg/kg, ip) significantly increased choice accuracy as evaluated in the five-choice task performed using a short stimulus duration. Ciproxifan (0.15-2 mg/kg, po) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats. Ciproxifan (10 mg/kg ip) enhances prepulse inhibition in the DBA/2 strain mice. It (3 mg/kg ip) alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Ciproxifan (3 mg/kg ip) improves accuracy and decreased impulsivity in adult male hooded Lister rats.
references[1] ligneau x1, lin j, vanni-mercier g, jouvet m, muir jl, ganellin cr, stark h, elz s, schunack w, schwartz j. neurochemical and behavioral effects of ciproxifan, a potent histamine h3-receptor antagonist. j pharmacol exp ther. 1998 nov; 287(2):658-66.
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