3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮
| 中文名称 | 3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 |
|---|---|
| 中文同义词 | 3-[二(4-甲氧基苯基)亚甲基]-1,3-二氢-2H-吲哚-2-酮;TAS-301游离态;化合物TAS-301;TAS 301,平滑肌细胞迁移和增殖的抑制剂 |
| 英文名称 | TAS-301 |
| 英文同义词 | 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one;3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one;CS-1543;TAS 301.TAS301;TAS-301;TAS 301.TAS301;2H-Indol-2-one,3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-;Protein kinase C,inhibit,Inhibitor,TAS301,PKC,TAS-301 |
| CAS号 | 193620-69-8 |
| 分子式 | C23H19NO3 |
| 分子量 | 357.4 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;Inhibitors |
| Mol文件 | 193620-69-8.mol |
| 结构式 |  |
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | 二甲基亚砜：40 mg/毫升 |
| 形态 | 固体 |
TAS-301是平滑肌细胞迁移和增殖的抑制剂，在大鼠颈动脉球囊损伤后抑制内膜增厚。TAS-301 可抑制PDGF诱导的 PKC 激活。
| Target | Value |
|
PKC
() |
TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca 2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.
TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | S6424 | 3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 5mg | 877.31元 |
| 2023/03/20 | S6424 | 3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 25mg | 2596.51元 |