| Company Name: |
TLC PharmaChem Inc.
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| Tel: |
(905) 268-0252 |
| Email: |
research@tlcpharmachem.com |
| Products Intro: |
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| | FROVATRIPTAN Basic information |
| Product Name: | FROVATRIPTAN | | Synonyms: | | | CAS: | | | MF: | C14H17N3O | | MW: | 243.31 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![FROVATRIPTAN Structure]() |
| | FROVATRIPTAN Chemical Properties |
| | FROVATRIPTAN Usage And Synthesis |
| General Description | Frovatriptan is a newer triptan introduced into the market in2001. With the incorporation of a 3-alkylamino side chaininto a carbazole ring structure, it is not a substrate forMAO-A or CYP3A4. Thus, unlike the other clinicallyavailable triptans, it possesses a much longer duration ofaction with fewer drug–drug interactions with MAO inhibitorsor with drugs metabolized by the CYP3A4isozymes. It is primarily metabolized by CYP1A2 togive its active metabolite, N-desmethyl-frovatriptan, whichhas about one third of the binding affinity for 5-HT1D/1B receptorsbut with three times longer plasma half-life of theparent drug.
Frovatriptan also has the highest affinity for brain 5-HT1B receptors and the longest elimination half-life amongall triptans. The only disadvantage of this drug is itsslower onset of action because of its greater water solubility.However, it is a drug of choice for patients with longlastingmigraines or if recurrence is a problem. |
| | FROVATRIPTAN Preparation Products And Raw materials |
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