| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:AZD9898
CAS:2042347-69-1
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
Chunchuang (Wuhan) Technology Co., Ltd
|
| Tel: |
15342225168 |
| Email: |
yutianchun2007@126.com |
| Products Intro: |
Product Name:1mg;1g;10g;100g;1Kg;
CAS:2042347-69-1
Purity:99.5+HPLC Package:1000g/RMB 10000
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:AZD9898;AZD-9898,AZD9898
CAS:2042347-69-1
Purity:98.27% Package:1 mg;10 mg;100 mg;2 mg;5 mg
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| | AZD9898 Basic information |
| Product Name: | AZD9898 | | Synonyms: | AZD9898;Cyclopropanecarboxylic acid, 2-[[5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxy-2-pyrazinyl]carbonyl]-, (1S,2S)-;AZD-9898,AZD9898 | | CAS: | 2042347-69-1 | | MF: | C20H19ClF3N3O4 | | MW: | 457.83 | | EINECS: | | | Product Categories: | | | Mol File: | 2042347-69-1.mol |  |
| | AZD9898 Chemical Properties |
| Boiling point | 633.8±55.0 °C(Predicted) | | density | 1.463±0.06 g/cm3(Predicted) | | pka | 3.58±0.11(Predicted) |
| | AZD9898 Usage And Synthesis |
| Biological Activity | AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].
AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1]. | | References | [1]. Munck Af Rosensch?ld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30. |
| | AZD9898 Preparation Products And Raw materials |
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