Denatonium Benzoate Anhydrous

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Company Name: Zhejiang Synose Tech Co., Ltd
Tel: 86-579-82270620
Products Intro: Product Name:Denatonium Benzoate Solutions
Purity:25%, 20%, 4% Package:25KG
Company Name: Shanghai Worldyang Chemical Co.,Ltd.
Tel: +86-13651600618;+86-21-56795779
Products Intro: Product Name:Denatonium benzoate
Purity:98% Package:25KG;1USD
Company Name: Wuhan Fortuna Chemical Co., Ltd
Tel: 86-27-59207850
Products Intro: Product Name:Denatonium Benzoate
Purity:99.5~101.0%,USP35 Package:1Kg/Bag;0USD|25Kg/Drum;USD
Company Name: Hebei Crovell Biotech Co Ltd
Tel: 19930504644 whatsapp +8619930504644
Products Intro: Product Name:denatonium benzoate
Purity:99.5% Package:1KG;10USD
Company Name: Shanghai Biolang Biotechnology Co., Ltd.
Products Intro: Product Name:Denatonium Benzoate Anhydrous
Purity:99.99% Package:1Kg/Bag;99.99USD

Lastest Price from Denatonium Benzoate Anhydrous manufacturers

  • Denatonium
  • US $48.00-40.00 / KG
  • 2021-10-19
  • CAS:3734-33-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200tons
  • US $20.00 / KG
  • 2021-10-15
  • CAS:3734-33-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 300 Tons/ year
Denatonium Benzoate Anhydrous Basic information
The most bitter compound in the world Chemical structure Uses
Product Name:Denatonium Benzoate Anhydrous
Synonyms:N,N-DIETHYL-N-[(2,6-DIMETHYLPHENYLCAR-BAMOYL)METHYL]BENZYLAMMONIUM BENZOATE;N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-benzenemethanaminium benzoate;REJEXIT (R);benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Bitrex? Denatonium Benzoate;Denatoniumbenzoate,96%;Acetylthio-2-Methylpro-Panoyl Chloride;DenatoniumBenzoate,Granular,Usp
Product Categories:DIMETANE;Miscellaneous Biochemicals;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;Pharmaceutical Intermediates
Mol File:3734-33-6.mol
Denatonium Benzoate Anhydrous Structure
Denatonium Benzoate Anhydrous Chemical Properties
Melting point 164-168 °C (lit.)
Boiling point 555.91°C (rough estimate)
density 1.1256 (rough estimate)
refractive index 1.5800 (estimate)
Fp 100℃
storage temp. Inert atmosphere,Room Temperature
solubility methanol: 50 mg/mL, clear, colorless
Merck 14,2891
BRN 8179408
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference3734-33-6(CAS DataBase Reference)
EPA Substance Registry SystemDenatonium benzoate (3734-33-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36-37/39
WGK Germany 2
RTECS BO6650000
HS Code 29242995
MSDS Information
Denatonium Benzoate Anhydrous Usage And Synthesis
The most bitter compound in the worldDenatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit.
Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear.
Chemical structureDenatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino.
UsesFlavoring agent.
Chemical Propertieswhite crystals
Chemical PropertiesDenatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules.
UsesH1 antihistamine
UsesPharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol.
Production MethodsDenatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
Brand nameBitrex (Mac Farlan Smith, Scotland).
Pharmaceutical ApplicationsDenatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol.
In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation.
SafetyDenatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
storageDenatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
IncompatibilitiesDenatonium benzoateis incompatible with strongoxidizing agents.
Regulatory StatusDenatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).
Denatonium Benzoate Anhydrous Preparation Products And Raw materials
Tag:Denatonium Benzoate Anhydrous(3734-33-6) Related Product Information
Diethyl ether Benzyl bromide Anthranilic acid Benzyl benzoate Benzoic acid AMMONIUM Benzyl chloride Cisatracurium besylate Denatonium Benzoate Monohydrate DENATONIUM BENZOATE SOLUTIONS DENATONIUM BENZOATE TABLET AMINO ACIDS Estradiol benzoate Denatonium Benzoate Anhydrous Benzyltrimethylammonium chloride Benzyltriethylammonium chloride ALTRENOGEST Phenylacetone