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| | 2-P-ANISYL-1,3-INDANDIONE Basic information |
| Product Name: | 2-P-ANISYL-1,3-INDANDIONE | | Synonyms: | ANISINDIONE;2-P-ANISYL-1,3-INDANDIONE;1,3-Indandione, 2-(p-methoxyphenyl)-;1H-Indene-1,3(2H)-dione, 2-(4-methoxyphenyl)-;2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione;2-(4-methoxyphenyl)indan-1,3-dione;2-(p-Methoxyphenyl)-1,3-indandione;2-(p-methoxyphenyl)-3-indandione | | CAS: | 117-37-3 | | MF: | C16H12O3 | | MW: | 252.26 | | EINECS: | 204-186-6 | | Product Categories: | Inhibitors;OPTIRAY | | Mol File: | 117-37-3.mol |  |
| | 2-P-ANISYL-1,3-INDANDIONE Chemical Properties |
| Melting point | 156-157° | | Boiling point | 355.44°C (rough estimate) | | density | 1.1824 (rough estimate) | | refractive index | 1.5600 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly) | | form | Solid | | pka | pKa 4.13(H2O t=25.0±0.1 I=0.1(NaCl)) (Uncertain) | | color | White to Off-White | | EPA Substance Registry System | Anisindione (117-37-3) |
| RIDADR | 2811 | | HazardClass | 6.1(b) | | PackingGroup | III | | Hazardous Substances Data | 117-37-3(Hazardous Substances Data) | | Toxicity | mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 28, Pg. 1591, 1985. |
| | 2-P-ANISYL-1,3-INDANDIONE Usage And Synthesis |
| Chemical Properties | Slightly beige or yellow powder | | Originator | Miradon,Schering,US,1960 | | Uses | radiopaque agent | | Uses | Anisindione is a synthetic anticoagulant that prevents the formation of active procoagulation factors and proteins in the liver. | | Definition | ChEBI: A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position. | | Manufacturing Process | To a hot solution of 20.6 g of sodium in 400 ml of absolute ethanol, there is
added a solution of 110 g of phthalide and 110 g of p-methoxybenzaldehyde.
A vigorous reaction ensues and one-half of the alcohol is distilled off over a
two hour period. Ice and water are added to the red solution and the diluted
solution is acidified with hydrochloric acid. The resulting gum solidifies and the
aqueous phase is removed by decantation. The crude solid is recrystallized
twice from two liters of ethanol yielding 2-(p-methoxyphenyl)-1,3-indandione
as pale yellow crystals, MP 155-156°C. | | Brand name | Miradon (Schering). | | Therapeutic Function | Anticoagulant | | General Description | Anisindione, 2-(p-methoxyphenyl)-1,3-indandione, 2-(p-anisyl)-1,3-indandione (Miradon), is ap-methoxy congener of phenindione. It is a white, crystallinepowder, slightly soluble in water, tasteless, and absorbedwell after oral administration.
In instances when the urine may be alkaline, an orangecolor may be detected. This is caused by metabolic productsof anisindione and is not hematuria. | | Purification Methods | Crystallise anisidinone from acetic acid or EtOH. [Horeau & Jacqius Bull Soc Chim Fr 53 1948, Koelsch J Am Chem. Soc 58 1331 1936, Beilstein 8 III 2931.] |
| | 2-P-ANISYL-1,3-INDANDIONE Preparation Products And Raw materials |
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