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Rhodamine 123

Rhodamine 123 Suppliers list
Tel: 21-51619050
Products Intro: CAS:62669-70-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Products Intro: Product Name:Rhodamine 123
Purity:95%-99% Package:1kg;1USD
Company Name: BOC Sciences
Tel: +16314854226
Products Intro: Product Name:Rhodamine-123
Package:50 mg Remarks:Rhodamine-123 is a cell-permeant green-fluorescent probe that is taken up by active mitochondria.
Company Name: Chongqing Chemdad Co., Ltd
Tel: +undefined-86-13650506873 +undefined-86-13650506873
Products Intro: Product Name:Rhodamine 123
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Tel: 0371-55170695
Products Intro: CAS:62669-70-9
Purity:0.99 Package:25KG;5KG;1KG;500G

Rhodamine 123 manufacturers

  • Rhodamine 123
  • $1.00 / 1kg
  • 2019-07-06
  • CAS:62669-70-9
  • Min. Order: 1kg
  • Purity: 95%-99%
  • Supply Ability: 1000kg
Rhodamine 123 Basic information
Product Name:Rhodamine 123
Synonyms:Rhodamine methyl ester hydrochloride;Rhodamin 123 Chloride, laser grade;2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester monohydrochloride;Benzoic acid, 2-(6-amino-3-imino-3H-xanthen-9-yl)-, methyl ester, monohydrochloride;Xanthylium, 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)-, chloride;Rhodamine 123 ,98%;RHODAMINE 123, 99+%, PURE;Rhodamine 123, pure
Product Categories:Xanthene;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorescent Labels & Indicators;ROX
Mol File:62669-70-9.mol
Rhodamine 123 Structure
Rhodamine 123 Chemical Properties
Melting point 235 °C
density 1.2224 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility ethanol: 20 mg/mL, clear, red
form Powder
color Red-brown to brown or dark green
Water Solubility Partially soluble
λmax501 nm, 507 nm
BRN 6030951
Major ApplicationColored bubbles; color filters; liquid crystal displays; light-emitting diodes; luminescent materials;nanophotonic composites; paints; semiconductor electrodes;solar cells
Biological ApplicationsMeasuring membrane potential; detecting cancer cells,spores,prostate cancer,stress biomarkers; treating disc degenerative disease,epilepsy,erectile dysfunction; apoptosis assays; tumor cell multidrug resistance assay; implantable
CAS DataBase Reference62669-70-9(CAS DataBase Reference)
EPA Substance Registry SystemXanthylium, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-, chloride (62669-70-9)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
WGK Germany 3
RTECS ZE0883000
HS Code 32049010
MSDS Information
Rhodamine 123 Usage And Synthesis
DescriptionRhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells. Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation. Rhodamine 123 has excitation/emission maxima of 507/529 nm.
Chemical Propertiesred-brown to brown or dark green powder
UsesUseful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.
UsesRhodamine-123 lycoprotein (P-gp) functional efflux activity in vivo. Rhodamine-123 PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid).
UsesRhodamine derivative, a fluoresent dye-labeled compound.
UsesFluorescent dye most commonly used as functional reporter in flow cytometry.
UsesRhodamine-123 is a fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Rhodamine 123 (R123), as a typical of P-glycoprotein substrate, was widely used to quantify P-glycoprotein (P-gp) functional efflux activity in vivo. Rhodamine-123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid).
in vitrorhodamine 123, which was identified as a member of the rhodamine family of flurone dyes, was used to examine membrane transport by the abcb1 gene product, mdr1. previous study determined the λmax for excitation and emission for rhodamine 123 in commonly used solvents and extraction buffers, indicating that the fluorescence of rhodamine 123 was highly dependent on the chemical environment. the optimal parameters are 1% methanol in hbss. in addition, the uptake of rhodamine 123 into cells was via both passive and active processes, and this occurred mainly by oatp1a2-mediated transport. furthermore, this previous study quantified the intracellular sequestration and metabolism of rhodamine 123, showing that these were both cell line-dependent factors that might influence the interpretation of transport assays [1].
references[1] samantha forster et al. characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. plos one. 2012; 7(3): e33253.
Tag:Rhodamine 123(62669-70-9) Related Product Information
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