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Trimethoprim

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Products Intro: Product Name:Trimethoprim
CAS:738-70-5
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine.
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CAS:738-70-5
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CAS:738-70-5
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CAS:738-70-5
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Lastest Price from Trimethoprim manufacturers

  • Trimethoprim
  • US $0.00 / mg
  • 2020-05-28
  • CAS:738-70-5
  • Min. Order: 100mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 100 g
  • Trimethoprim
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  • 2020-05-03
  • CAS:738-70-5
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Trimethoprim Basic information
Pyrimethamine class antibacterial agents Side effects Chemical Properties Uses Production methods
Product Name:Trimethoprim
Synonyms:methoxybenzyl aminopyrimidine;Trimethopim(TMP);TRIMETHOPRIM, CRYSTALLIZED;TRIMETHOPRIM VETRANAL, 250 MG;5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine;Antibiotic synergist;trimethoprim crystalline;TRIMETHOPRIM BP
CAS:738-70-5
MF:C14H18N4O3
MW:290.32
EINECS:212-006-2
Product Categories:Thiophenes;Pharmaceutical;Broad-spectrum antibacterials;API;TRIMPEX;antibiotic;Peptide Synthesis/Antibiotics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:738-70-5.mol
Trimethoprim Structure
Trimethoprim Chemical Properties
Melting point 199-203 °C
Boiling point 432.41°C (rough estimate)
density 1.1648 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
pka6.6(at 25℃)
form white powder
color colorless or white
Water Solubility <0.1 g/100 mL at 24 ºC
Merck 14,9709
BRN 625127
Stability:Stable. Incompatible with strong oxidizing agents, acids.
CAS DataBase Reference738-70-5(CAS DataBase Reference)
NIST Chemistry ReferenceTrimethoprim(738-70-5)
EPA Substance Registry SystemTrimethoprim (738-70-5)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45-24/25
RIDADR 3249
WGK Germany 3
RTECS UV8225000
8-10-21
HazardClass 6.1(b)
PackingGroup III
HS Code 29335995
Hazardous Substances Data738-70-5(Hazardous Substances Data)
ToxicityLD50 orally in mice: 7000 mg/kg (Yamamoto)
MSDS Information
ProviderLanguage
Trimethoprim English
SigmaAldrich English
Trimethoprim Usage And Synthesis
Pyrimethamine class antibacterial agentsTrimethoprim is a lipophilic and weak alkaline pyrimethamine class bacteriostatic agent. It is a white or almost white crystalline powder, odorless, bitter, and slightly soluble in chloroform, ethanol or and acetone, but almost insoluble in water and highly soluble in glacial acetic acid solution. It has an antibacterial spectrum which is similar with sulfa drugs, but with a strong antibacterial effect. It has a good effect on treating Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, and a variety of other gram-positive and negative bacteria. But it is ineffective against Pseudomonas aeruginosa infection. Its minimum inhibitory concentration is often less than 10 mg/L with using alone being easy to cause bacterial resistance, and thus it is generally not used alone, and mainly combined with sulfa drug to form compound preparation for clinical treatment of urinary tract infections, intestinal infections, respiratory infections, dysentery, enteritis, typhoid fever, meningitis, otitis media, meningitis, sepsis and soft tissue infections. It has an effect on treating typhoid and paratyphoid effect which is not less than ampicillin; It can also be combined with long-acting sulfa drugs for prevention and treatment of drug-resistant falciparum malaria.
The basic principle of anti-bacterial of trimethoprim is to interfere with folate metabolism in bacteria. The main mechanism of action is the selective inhibition of the activity of dihydrofolate reductase in bacteria so that dihydrofolate can’t be reduced to tetrahydrofolate. Since the synthesis of folic acid is the main part of a nucleic acid biosynthesis, and therefore the product prevents bacterial nucleic acids and proteins synthesis. Moreover, the binding affinity of trimethoprim (TMP) to bacterial dihydrofolate reductase enzyme is five times as strong as that to the mammalian dihydrofolate reductase. The combination between it with sulfa drugs can cause dual blockage to the folic acid biosynthesis metabolism of bacteria so that there is a synergistic effect which will enhance the antibacterial activity of sulfa drugs, and can turn antibacterial effect to bactericidal effect which reduce the drug-resistant strains. In addition, the product can also enhance the antibacterial effects of a variety of other antibiotics (such as tetracycline, gentamicin).
Side effectsTrimethoprim (referred to as the TMP) has a low toxicity with commonly used dose causing rare cases of adverse reactions. Since the product can interfere with folate metabolism which may cause patients’ suffer from some adverse reactions of blood systems such as anemia, leukopenia and thrombocytopenia. This is commonly observed in cases of overdose or long duration of application. Therefore, during the treatment, it is necessary to regularly check blood condition. This product has the maximum daily dosage being lower than 0.5g with continuous medication time being less than one week. Upon blood system adverse reaction, the patient can orally administrate folic acid preparation for treatment. This product is not suitable to be simultaneously combined with anticancer drugs, antiepileptic drugs and other folic acid antagonists used; the combination between TMP and SMZ or SD even can cause crystallization of urine. Other adverse reactions also include mild skin rash and gastrointestinal reactions.
Chemical PropertiesWhite crystalline powder, odorless, bitter taste. Melting point: 199-203 °C. It is insoluble in water, ether, benzene, and slightly soluble in chloroform, methanol, highly soluble in acetic acid.
Uses1. It can be used as a synergistic antimicrobial drugs; it can also be used for treating bacterial infections and coccidiosis in poultry.
2. It is a novel orally administrated broad-spectrum antibiotics. It has a similar antibacterial spectrum with sulfa drugs but with a stronger potency. It is effective in treating a variety of Gram positive and negative bacteria. Since the bacteria is easy to evolve drug resistance to this product, it is not suitable to be used alone as an antimicrobial drug. The combination between trimethoprim and sulfa drugs can enhance the antibacterial activity by several times to several dozens of times. The product is mainly used for being as the synergistic drugs for sulfonamide drugs with a general ratio of 1: 5 for usage. It can also be used as a veterinary drug for treatment of avian sepsis caused by Escherichia coli, salmonellosis, fowl typhoid, cholera, and respiratory system secondary bacterial infections. It can also be used for the treatment of coccidiosis.
3. Application: used as antibacterial synergistic drugs; treat respiratory tract infections, urinary tract infections and intestinal infections when being used alone.
The above information is edited by the chemicalbook of Dai xiongfeng.
Production methodsUse Trimethoxybenzaldehyde as raw material; first condense with methoxypropionitrile to produce 3'4'5'-trimethoxy-2-cyano-3-methoxy-propene; and cyclized together with guanidine nitrate in the presence of methanol/sodium methoxide.
DescriptionTrimethoprim selectivity between bacterial and mammalian dihydrofolate reductases results from the subtle but significant architectural differences between these enzyme systems. Whereas the bacterial enzyme and the mammalian enzyme both efficiently catalyze the conversion of dihydrofolic acid to tetrahydrofolic acid, the bacterial enzyme is sensitive to inhibition by trimethoprim by up to 40,000-fold lower concentrations than the mouse enzyme is. This difference explains the useful selective toxicity of trimethoprim.
Chemical PropertiesCrystalline
OriginatorEusaprim,Wellcome,Italy,1970
Usesanti-inflammatory
UsesAn antibacterial agent which selectively inhibits dihydrofolate reductase.
Manufacturing Process6 grams (0.26 mol) sodium was dissolved in 300 ml methanol under stirring and refluxing. 47.5 grams (0.55 mol) β-methoxypropionitrile and 98 grams (0.5 mol) 3,4,5-trimethoxybenzaldehyde were added and the mixture refluxed gently for 4 hours. The mixture was then chilled and 150 ml of water was added. The product crystallized rapidly. Crystallization was allowed to proceed at 5° to 10°C under stirring for 1 hour. The product was filtered by suction and washed on the filter with 200 ml of 60% ice cold methanol. The crude material was air-dried and used for further steps without purification. It melted at 78° to 80°C. A pure sample, recrystallized from methanol, melted at 82°C. The yield of 3,4,5-trimethoxy-2'-methoxymethylcinnamonitrile was 92 grams, corresponding to 70% of the theory.
19 grams (0.83 mol) sodium was dissolved in 300 ml methanol, 106 grams of 3,4,5-trimethoxy-2'-methoxymethylcinnamonitrile was added and the mixture gently refluxed for 24 hours. The solution, which had turned brown, was poured into 1 liter of water and the precipitated oil extracted repeatedly with benzene. The combined benzene layers (500 to 700 ml) were washed 3 times with 500 ml of water, the benzene removed by evaporation in a vacuum from a water bath, and the brown residual oil distilled in vacuo, boiling point 215° to 225°C/11 mm. The clear, viscous oil, 3,4,5-trimethoxy-2'-cyano_x0002_dihydrocinnamaldehyde dimethyl acetal, weighed 83 grams (71% of the theory), and showed a nD23 = 1.5230. It solidified upon standing. A sample recrystallized from methanol melted at 69° to 70°C and showed a strong melting point depression with the starting material; nD25 = 1.5190. 31.5 grams (0.107 mol) 3,4,5-trimethoxy-2'-cyano-dihydrocinnamaldehyde dimethyl acetal was refluxed with methanolic guanidine solution (200 ml containing 0.25 mol of guanidine) for 2 hours. The methanol completely distilled off under stirring, finally from a bath of 110° to 120°C until the residue solidified completely to a yellowish crystalline mass. After allowing to cool, it was slurried with 100 ml of water and collected by vacuum filtration and dried. The yield of 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine amounted to 28 grams (91% of the theory). The material showed the correct melting point of 199° to 200°C and was, however, yellowish discolored. 20 grams of the above product was added to 30 ml of 3 N aqueous sulfuric acid at 60°C under stirring. The solution was chilled under stirring to 5° to 10°C. The crystalline sulfate was collected by vacuum filtration and washed on the filter twice with 10 ml of cold 3 N aqueous sulfuric acid each time. From the filtrate there was recovered 1.3 grams (6.5%) of discolored material melting at 195° to 196°C and which can be added to subsequent purification batches.
The sulfate on the filter was dissolved in 200 ml of hot water, the solution charcoaled hot, and the product precipitated from the clear colorless filtrate by the gradual addition of a solution of 20 grams of sodium hydroxide in 40 ml of water under chilling. The precipitate was filtered by suction and washed thoroughly with water on the filter. The white material, 17.5 grams (88%) showed the correct melting point of 200° to 201°C, according to US Patent 3,341,541.
Brand nameProloprim (Monarch); Trimpex (Roche).
Therapeutic FunctionAntibacterial (urinary)
General DescriptionOdorless white powder. Bitter taste.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileTrimethoprim readily forms salts with acids. .
Fire HazardFlash point data for Trimethoprim are not available. Trimethoprim is probably combustible.
Clinical UseTrimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.
Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.
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