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GLIOTOXIN

GLIOTOXIN Suppliers list
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897
Email: maggie@biopurify.com
Products Intro: Product Name:Gliotoxin
CAS:67-99-2
Purity:98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP1769
Company Name: Chengdu GLP Biotech Co., Ltd
Tel: 13350802083
Email: scglp@glp-china.com
Products Intro: Product Name:Gliotoxin
CAS:67-99-2
Purity:98% Package:1g;5g;10g
Company Name: Chengdu Greenpure Biopharma CO.,Ltd
Tel: 18283602253
Email: jancyzheng@gcgreenpure.com
Products Intro: Product Name:Gliotoxin
CAS:67-99-2
Purity:98% Package:20mg;100mg;1g Remarks:Miscellaneous
Company Name: J & K SCIENTIFIC LTD.  
Tel: 400-666-7788 +86-10-82848833
Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:Gliotoxin, 98%, from Gliocladium fimbriatum
CAS:67-99-2
Purity:98% Package:1MG;5MG
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:Gliotoxin;(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxyMethyl)-2-Methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
CAS:67-99-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
GLIOTOXIN Basic information
Product Name:GLIOTOXIN
Synonyms:GLIOTOXIN;GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM;Gliotoxin, 99%, from Gliocladium fimbriatum;10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox;2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE;(3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl;aspergillin;s.n.12870
CAS:67-99-2
MF:C13H14N2O4S2
MW:326.39
EINECS:636-170-3
Product Categories:antibiotic
Mol File:67-99-2.mol
GLIOTOXIN Structure
GLIOTOXIN Chemical Properties
Melting point 221°C (rough estimate)
alpha D25 -290° (c = 0.08 in ethanol)
density 1.4069 (rough estimate)
refractive index 1.6510 (estimate)
Fp 2℃
storage temp. 2-8°C
solubility chloroform: 10 mg/mL, clear, colorless
form White solid
Merck 13,4454
BRN 50675
Safety Information
Hazard Codes T,Xn,F
Risk Statements 25-36-20/21/22-11
Safety Statements 36/37/39-45-36/37-16
RIDADR UN 3462 6.1/PG 3
WGK Germany 3
RTECS KB4725000
4.2-10-23
HazardClass 6.1(b)
PackingGroup III
HS Code 29419090
MSDS Information
ProviderLanguage
SigmaAldrich English
GLIOTOXIN Usage And Synthesis
Chemical PropertiesWhite powder
UsesGliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the re gulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent.
UsesGliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin inhibits a broad range of unrelated mechanisms, including inhibition of chymotrypsin-like activity of the 20S proteasome and Ca2+ release from mitochondria, activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells, anti-inflammatory activity, and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction with proteins through mixed disulphide formation. Gliotoxin inhibits a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.
DefinitionChEBI: A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.
HazardPoison.
Biological ActivityImmunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I κ B α , an endogenous blocker of NF- κ B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC 50 values are 80 and 17 μ M respectively) and displays antitumor activity against breast cancer in vivo .
Purification MethodsPurify gliotoxin by recrystallisation from MeOH. Its solubility in CHCl3 is 1%. The dibenzoyl derivative has m 202o (from CHCl3/MeOH). [Glister & Williams Nature 153 651 1944, Elvidge & Spring J Chem Soc Suppl 135 1949, Johnson et al. J Am Chem Soc 65 2005 1943, Bracken & Raistrick Biochem J 41 569 1947.]
GLIOTOXIN Preparation Products And Raw materials
Tag:GLIOTOXIN(67-99-2) Related Product Information
isopropyl propyl disulphide (R)-2-ETHYL-PIPERAZINE GLIOTOXIN 1-ETHYLPIPERAZIN-2-ONE HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE CYCLO(-ALA-ALA) CYCLO(-ALA-GLY) 1-ISOPROPYL-PIPERAZIN-2-ONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE 1-(3-PENTYL)-PIPERAZINE (S)-1-ISOPROPYL-2-METHYL-PIPERAZINE Piperazin-2-one 2,5-Dimethylpiperazine N,N,N',N'-TETRAMETHYL-1,2-DIAMINOPROPANE N,N-Dipropylpropionamide BUTYL ETHYL DISULPHIDE 1,5-HEXADIEN-3-OL 1,3-CYCLOHEXADIENE