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| | AC-YVAD-AFC Basic information |
| Product Name: | AC-YVAD-AFC | | Synonyms: | CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC;AC-YVAD-AFC;AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN;AC-TYR-VAL-ALA-ASP-AFC;M.W. 719.67 C33H36F3N5O10;N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin);N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;CASPASE-1 SUBSTRATE XII, FLUOROGENIC | | CAS: | 219137-85-6 | | MF: | C33H36F3N5O10 | | MW: | 719.66 | | EINECS: | | | Product Categories: | Caspase/Related Products;Pepetides;Caspases/Apoptosis;peptide | | Mol File: | 219137-85-6.mol |  |
| | AC-YVAD-AFC Chemical Properties |
| Melting point | >190°C (dec.) | | Boiling point | 1084.6±65.0 °C(Predicted) | | density | 1.416±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO (Slightly), Methanol (Silghtly) | | form | powder | | pka | 4.09±0.10(Predicted) | | color | white |
| | AC-YVAD-AFC Usage And Synthesis |
| Description | Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. | | Uses | N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research. | | Definition | ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin. | | Biological Activity | Fluorogenic peptide substrate for caspase-1 (ICE). |
| | AC-YVAD-AFC Preparation Products And Raw materials |
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