3-DEAZA-2'-DEOXYADENOSINE manufacturers
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| | 3-DEAZA-2'-DEOXYADENOSINE Basic information |
| Product Name: | 3-DEAZA-2'-DEOXYADENOSINE | | Synonyms: | 1H-Imidazo[4,5-C]pyridin-4-amine, 1-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)-;3-Deaza-2'-da;Aids002055;Aids-002055;1H-Imidazo[4,5-c]pyridin-4-amine, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-;1-(2-Deoxy-β-D-erythro -pentofuranosyl)-1H -
imidazo[4,5-c ]pyridin-4-amine;3-Deaza-2'-deoxyadenosine;3'-Deazaadenosine | | CAS: | 78582-17-9 | | MF: | C11H14N4O3 | | MW: | 250.25 | | EINECS: | | | Product Categories: | | | Mol File: | 78582-17-9.mol |  |
| | 3-DEAZA-2'-DEOXYADENOSINE Chemical Properties |
| Melting point | 208-209 °C | | Boiling point | 617.7±65.0 °C(Predicted) | | density | 1.75±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 13.88±0.60(Predicted) |
| | 3-DEAZA-2'-DEOXYADENOSINE Usage And Synthesis |
| Uses | 3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity[1][2]. | | References | [1] Hendrickson CL, et al. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Res. 2004 Apr 23;32(7):2241-50. DOI:10.1093/nar/gkh542
[2] Cristalli G, et al. Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. J Med Chem. 1995 Sep 29;38(20):4019-25. DOI:10.1021/jm00020a017 |
| | 3-DEAZA-2'-DEOXYADENOSINE Preparation Products And Raw materials |
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