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METHAQUALONE HYDROCHLORIDE

METHAQUALONE HYDROCHLORIDE Basic information
Product Name:METHAQUALONE HYDROCHLORIDE
Synonyms:mtqhydrochloride;2-METHYL-3-[2-METHYLPHENYL]-4[3H]-QUINAZOLINONE HYDROCHLORIDE;METHAQUALONE HYDROCHLORIDE;METHAQUALONE HYDROCHLORIDE--DEA*SCHEDULE I ITEM;4(3H)-Quinazolinone, 2-methyl-3-(2-methylphenyl)-, monohydrochloride;Revonal hydrochloride;2-Methyl-3-tolylchinazolon-4 hydrochloride [german];2-Metil-3-(o-tolil)-4-chinazolone chloridrato [italian]
CAS:340-56-7
MF:C16H15ClN2O
MW:286.76
EINECS:206-431-2
Product Categories:
Mol File:340-56-7.mol
METHAQUALONE HYDROCHLORIDE Structure
METHAQUALONE HYDROCHLORIDE Chemical Properties
Melting point 255-265°
Fp 11 °C
storage temp. 2-8°C
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-39/23/24/25-23/24/25-11
Safety Statements 7-16-36/37-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS VA4025000
HazardClass 6.1(b)
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
METHAQUALONE HYDROCHLORIDE Usage And Synthesis
OriginatorQuaalude ,Lemmon,US,1965
Manufacturing ProcessAnthranilic acid (1 part) is dissolved in acetic anhydride (2 parts) and the temperature raised progressively to 190° to 200°C while distillation takes place. The last traces of acetic acid are removed under vacuum and, after cooling to about 50° to 60°C, o-toluidine (1 part) is added in portions.
The temperature is then raised to 170° to 200°C when the excess water and o-toluidine is gradually distilled off, finally maintaining the temperature at 180° to 200°C for 2 hours. After cooling to about 100°C dilute hydrochloric acid (3 parts) is added and the mixture boiled and stirred. The solution is then neutralized with NaOH with stirring and the product which separates is recrystallized twice from alcohol after decolorizing with carbon. Yield: 70% of theoretical, LIP 114° to 115°C.
Therapeutic FunctionHypnotic
Safety ProfilePoison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects. convulsions, dyspnea, pulse rate increase. When heated to decomposition it emits very toxic fumes of NOx and HCl.
METHAQUALONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsAcetic anhydride-->Anthranilic acid-->Hydrochloric acid-->o-Toluidine
Tag:METHAQUALONE HYDROCHLORIDE(340-56-7) Related Product Information
METHAQUALONE HYDROCHLORIDE METHAQUALONE 6,8-DICHLORO-2-(CHLOROMETHYL)-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 2-[(BUTYLSULFANYL)METHYL]-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(4-CHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(4-METHOXYPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 3-(4-CHLORO-2-METHYLPHENYL)-2-([(2-METHOXYPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-2-([(4-FLUOROPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE 2-(CHLOROMETHYL)-3-(4-CHLORO-2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 2-[(BENZYLSULFANYL)METHYL]-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(3-CHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-2-([(4-METHOXYPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE 3-(4-CHLORO-2-METHYLPHENYL)-2-([(2,6-DICHLOROPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(2,6-DICHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-3-(2-METHYLPHENYL)-2-(([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)METHYL)-4(3H)-QUINAZOLINONE 2-([(4-BROMOPHENYL)SULFANYL]METHYL)-6-CHLORO-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 2-([(4-BROMOPHENYL)SULFANYL]METHYL)-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 2-Metil-3-(2-carbossietildietilammino-6-metil-fenil)-4-chinazolone clo ridrate [Italian]