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Suberic acid

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CAS:505-48-6
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CAS:505-48-6
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CAS:505-48-6
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Products Intro: Product Name:suberic acid
CAS:505-48-6
Purity:99% Package:5KG;1KG Remarks:C8H14O4

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  • Suberic acid
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  • CAS:505-48-6
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Suberic acid Basic information
Product Name:Suberic acid
Synonyms:Subericacid,99%;142-144℃;STRYCHNINE (P);Hexane-1,6-dicarboxylic acid, Suberic acid;Cork Acid 1,6-Hexanedicarboxylic Acid Kork Acid Octanedioic Acid;Suberic aci;1.6-Hexanedica;Suberic acid purum, >=98.0% (T)
CAS:505-48-6
MF:C8H14O4
MW:174.19
EINECS:208-010-9
Product Categories:Pharmaceutical intermediates;Dicarboxylic Acids;Biochemicals and Reagents;Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fatty Acids and conjugates;Fatty Acyls;Lipids;Organic Building Blocks;Miscellaneous Natural Products;alpha,omega-Alkanedicarboxylic Acids;alpha,omega-Bifunctional Alkanes;Monofunctional & alpha,omega-Bifunctional Alkanes;bc0001
Mol File:505-48-6.mol
Suberic acid Structure
Suberic acid Chemical Properties
Melting point 140-144 °C(lit.)
Boiling point 230 °C15 mm Hg(lit.)
density 1.3010 (rough estimate)
bulk density700kg/m3
vapor pressure 0Pa at 22.85℃
refractive index 1.4370 (estimate)
Fp 203 °C
storage temp. Store below +30°C.
solubility 1.6g/l
form Powder
pka4.52(at 25℃)
color White to cream
PH3.79(1 mM solution);3.27(10 mM solution);2.76(100 mM solution);
Water Solubility 0.6 g/L (20 ºC)
Merck 14,8862
BRN 1210161
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, bases.
InChIKeyTYFQFVWCELRYAO-UHFFFAOYSA-N
LogP0.59 at 25℃ and pH7.08
CAS DataBase Reference505-48-6(CAS DataBase Reference)
NIST Chemistry ReferenceOctanedioic acid(505-48-6)
EPA Substance Registry SystemOctanedioic acid (505-48-6)
Safety Information
Hazard Codes Xi
Risk Statements 36-36/37/38
Safety Statements 26-39-36
WGK Germany 1
Autoignition Temperature430°C
TSCA Yes
HS Code 29171990
MSDS Information
ProviderLanguage
Octanedioic acid English
SigmaAldrich English
ACROS English
ALFA English
Suberic acid Usage And Synthesis
DescriptionIt was firstly produced by nitric acid oxidation of cork (Latin suber) material and then from castor oil. The oxidation of ricinoleic acid produces, by splitting at the level of the double bond and at the level of the OH group, at the same time, suberic acid (octanedioic acid) and the next homologue azelaic acid. Suberic acid was used in the manufacture of alkyd resins and in the synthesis of polyamides leading to nylon.
Chemical Propertiesoff-white crystalline powder
UsesIn the plastics industry.
UsesSuberic Acid is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.
DefinitionChEBI: An alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.
ReactionsSuberic acid is an essential chemical widespread in softwood trees' trunk. Can there be reactions such as esterification, carboxylic acid halides, amidation and reduction in suberic acid, generation pyrolysis is heated. Its main application is to react with dibasic alcohol and diamine, produce polyester and polymeric amide, and also for organic synthesis.
Synthesis Reference(s)Journal of the American Chemical Society, 81, p. 3677, 1959 DOI: 10.1021/ja01523a046
SynthesisIndustrial is to be obtained by Viscotrol C or ricinolic acid or cyclooctane oxidation, conventionally using 50% sulfuric acid to carry out catalysis. Suberic acid also can be oxidized and obtained by cyclooctene. A method for preparing suberic acid through cyclooctene oxidation comprises the following steps: mixing tetra-allkylammonium perrhenate and alkyl-imidazolim disulfate ionic liquid in a certain proportion to form a composite phase transfer catalyst and meanwhile carrying out catalytic oxidation reaction on cyclooctene in the presence of alkyl-imidazolim disulfate ionic liquid serving as a reaction solvent and a hydrogen peroxide solution serving as an oxidizing agent, wherein the reaction temperature is 40-70°C, the pressure is normal, and the reaction time is 0.5-4 hours. After the reaction, the gas chromatography detection shows that the conversion rate of the cyclooctene is above 90%, and the cyclooctene yield is above 60%.
Purification MethodsCrystallise it from acetone. It sublimes at 300o without decomposition. [Beilstein 2 IV 2028.]
Toxics Screening LevelThe initial threshold screening level (ITSL) for suberic acid is 17 μg/m3 based on an annual averaging time.
Tag:Suberic acid(505-48-6) Related Product Information
Sebacic acid Ethyl 2-(Chlorosulfonyl)acetate Azelaic acid Folic acid Suberic acid d,SUBERIC ACID DIETHYL ESTER Dibutyltin dilaurate SUBERIC ACID DIMETHYL ESTER Stearic acid Suberic acid 1-methyl ester,SUBERIC ACID MONOMETHYL ESTER,SUBERIC ACID METHYL ESTER spiro[indene-1,4'-piperidine] hydrochloride SPIRO[INDENE-1,4'-PIPERIDINE] 1-Octanol Citric acid Ascoric Acid DISUCCINIMIDYL SUBERATE BS3 dihexyl octanedioate octanedial

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