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24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Suppliers list
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| Company Name: |
Chengdu Push Bio-Technology Co., Ltd.
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| Tel: |
028-85370565-229 18080489829 |
| Email: |
3004654993@qq.com |
| Products Intro: |
Product Name:triptohypol C
CAS:193957-88-9
Purity:95% Package:5mg
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| Company Name: |
Shanghai Taopu Industrial Co., LTD
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| Tel: |
159-00573766 18018507602 |
| Email: |
394643792@qq.com |
| Products Intro: |
Product Name:Triptohypol C
CAS:193957-88-9
Purity:95% Package:10mg;20mg;50mg;1G;5G;34G
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Dihydrocelastrol
CAS:193957-88-9
Package:2mg/RMB 2480
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| | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Basic information |
| Product Name: | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- | | Synonyms: | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-;DHCE. (-)-Triptohypol C;Dihydrocelastrol;Triptohypol C | | CAS: | 193957-88-9 | | MF: | C29H40O4 | | MW: | 452.64 | | EINECS: | | | Product Categories: | | | Mol File: | 193957-88-9.mol |  |
| | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Chemical Properties |
| Boiling point | 596.0±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | pka | 4.79±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Usage And Synthesis |
| Uses | Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1]. | | Definition | ChEBI: Triptohypol C is a pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii. It has a role as a plant metabolite and an apoptosis inducer. It is a pentacyclic triterpenoid, a monocarboxylic acid and a member of benzenediols. | | in vivo | Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%). | Animal Model: | Zebrafish[1] | | Dosage: | 0.5?μM, 1?μM and 1.25?μM | | Administration: | 72 h | | Result: | Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25?μM for 24?h or at a concentration of 0.5?μM for 72?h. |
| | IC 50 | Nur77/NR4A1 | | References | [1] Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. DOI:10.1016/j.ejmech.2019.05.009 |
| | 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Preparation Products And Raw materials |
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