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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903 |
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| Products Intro: |
Product Name:8-Fluoro-3-(4-(4-fluorophenoxy)phenyl)-2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one
CAS:2314467-59-7
Purity:98% Package:5mg Remarks:S89979
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4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- manufacturers
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| | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Basic information |
| Product Name: | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- | | Synonyms: | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-;TRPV4 agonist-1 free base;OUN67600;Transient receptor potential channels,TRP Channel,Inhibitor,TRPV4 agonist1 free base,inhibit,TRPV4 agonist 1 free base,TRPV-4 agonist-1 free base,TRPV4 agonist-1;8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one;8-Fluoro-3-(4-(4-fluorophenoxy)phenyl)-2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one;TRPV4 agonist-1 free base, 10 mM in DMSO | | CAS: | 2314467-59-7 | | MF: | C25H22F2N4O2 | | MW: | 448.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2314467-59-7.mol | ![4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Structure](CAS/20200611/GIF/2314467-59-7.gif) |
| | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Chemical Properties |
| Boiling point | 580.6±60.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (185.81 mM; Need ultrasonic) | | pka | 7.16±0.42(Predicted) | | form | Solid | | color | White to off-white |
| | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Usage And Synthesis |
| Uses | TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1]. | | References | [1] Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28. DOI:10.1021/acs.jmedchem.8b01615 |
| | 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Preparation Products And Raw materials |
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