1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester manufacturers
- AZ3976
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- $48.00 / 5mg
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2025-11-09
- CAS:1418747-15-5
- Min. Order:
- Purity: 98.14%
- Supply Ability: 10g
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| | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester Basic information |
| Product Name: | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester | | Synonyms: | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester;1-Boc-3-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-azetidine;tert-Butyl 3-((4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate;tert-butyl 3-({4-oxo-1H,4H-pyrido[2,3-d]pyrimidin-2-yl}amino)azetidine-1-carboxylate;AZ3976, 10 mM in DMSO | | CAS: | 1418747-15-5 | | MF: | C15H19N5O3 | | MW: | 317.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1418747-15-5.mol | ![1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester Structure](CAS/20210111/GIF/1418747-15-5.gif) |
| | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester Chemical Properties |
| Boiling point | 490.3±55.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | pka | 1.11±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester Usage And Synthesis |
| Uses | AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50?value of 26 μM?in an enzymatic chromogenic assay. AZ3976 is active with an IC50?of 16 μM in a plasma clot lysis assay.?AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay[1]. | | References | [1] Ola Fjellstr?m, et al. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem. 2013 Jan 11;288(2):873-85. DOI:10.1074/jbc.M112.371732 |
| | 1-Azetidinecarboxylic acid, 3-[(3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-, 1,1-dimethylethyl ester Preparation Products And Raw materials |
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