地托咪定
中文名称 | 地托咪定 |
---|---|
中文同义词 | 地托咪定;地拖咪啶;4-(2,3-二甲苄基)-1H-咪唑;美托咪定杂质12;右美托嘧啶杂质D;右美托嘧啶杂质D;4-(2,3-二甲苄基)-1H-咪唑;美托咪定杂质26;去托米定 |
英文名称 | 4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE |
英文同义词 | 4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE;1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-;4-(2,3-Dimethylbenzyl)imidazol;90038-01-0 (Monohydrochloride);Detomidina;Detomidina [inn-spanish];Detomidine [inn:ban];detomidine |
CAS号 | 76631-46-4 |
分子式 | C12H14N2 |
分子量 | 186.25 |
EINECS号 | |
相关类别 | 杂质对照品;医用原料;医药原料 |
Mol文件 | 76631-46-4.mol |
结构式 |
地托咪定 性质
熔点 | 114-116° |
---|---|
沸点 | 386.5±11.0 °C(Predicted) |
密度 | 1.077±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 14.44±0.10(Predicted) |
颜色 | 白色至类白色 |
Currently, detomidine is only licenced for use in horses. Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.
安全信息
毒性 | LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela) |
---|