Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:Ethyl BiscouMacetate CAS:548-00-5 Package:100Mg,1g
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Company Name: |
LGM Pharma
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Tel: |
1-(800)-881-8210 |
Email: |
inquiries@lgmpharma.com |
Products Intro: |
Product Name:Ethyl BiscouMacetate CAS:548-00-5 Purity:Typically NLT 98%
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Company Name: |
Chemsky (shanghai) International Co.,Ltd
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Tel: |
021-50135380 |
Email: |
shchemsky@sina.com |
Products Intro: |
Product Name:Ethyl BiscouMacetate CAS:548-00-5 Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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Ethyl Biscoumacetate manufacturers
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| Ethyl Biscoumacetate Basic information |
| Ethyl Biscoumacetate Chemical Properties |
Melting point | 177-182° and mp 154-157° | Boiling point | 448.92°C (rough estimate) | density | 1.3259 (rough estimate) | refractive index | 1.4480 (estimate) | storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere | solubility | Chloroform (Slightly), DMSO (Slightly) | form | Solid | pka | pKa 7.5 (Uncertain) | color | White | Water Solubility | 54.31mg/L(temperature not stated) |
RIDADR | 2811 | HazardClass | 6.1(b) | PackingGroup | III | Toxicity | LD50 in mice, rats (g/kg): 0.88, 0.26 orally; 0.32, 1.1 i.p. (Gruber) |
| Ethyl Biscoumacetate Usage And Synthesis |
Chemical Properties | White, crystalline solid; odorless; bitter
taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water. | Originator | Tromexan,Geigy,US,1950 | Uses | Anticoagulant. | Uses | Medicine (anticoagulant). | Definition | A synthetic derivative of bishydroxycoumarin. | Manufacturing Process | 7 g of benzotetronic acid are dissolved in 750 cc of water at boiling
temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl
alcoholate are added. After a short while the liquid becomes turbid and
gradually a white deposit is separated. The deposit is filtrated and dried in
vacuo. The melting point is 172°C to 174°C; after recrystallization from
methyl alcohol 153°C to 154°C. The crude product is dissolved in sodium lye, filtrated by means of animal
charcoal precipitated by means of hydrochloric acid, and recrystallized from
methyl alcohol. The melting point is 153°C to 154°C. | Therapeutic Function | Anticoagulant | Synthesis | Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy-
3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine,
but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde. |
| Ethyl Biscoumacetate Preparation Products And Raw materials |
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