SJ6986 manufacturers
- SJ6986
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- $48.00
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2026-06-02
- CAS:2765625-93-0
- Purity: 99.73%
- Supply Ability: 10g
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| Product Name: | SJ6986 | | Synonyms: | SJ6986;SJ6986,SJ-6986;Benzenesulfonamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-;N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide;N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-benzenesulfonamide;SJ6986, 10 mM in DMSO;SJ6986 ，E1300;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide | | CAS: | 2765625-93-0 | | MF: | C20H14F3N3O7S | | MW: | 497.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2765625-93-0.mol |  |
| | SJ6986 Chemical Properties |
| density | 1.651±0.06 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml | | form | A crystalline solid | | pka | 5.87±0.20(Predicted) | | color | White to yellow |
| | SJ6986 Usage And Synthesis |
| Description | SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator. | | Uses | SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. | | in vivo | SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice[1]. | | storage | Store at -20°C | | References | [1] Gisele Nishiguchi, et al. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. J Med Chem. 2021 May 27. DOI:10.1021/acs.jmedchem.0c01313 |
| | SJ6986 Preparation Products And Raw materials |
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