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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Suppliers list
Company Name: TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
Tel: +86-576-88902229;+86-0576-88902229 +8613968687450
Email: yuxin@yuxchem.com
Products Intro: Product Name:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-amine
CAS:477600-74-1
Purity:98% Package:1KG.5KG;25KG
Company Name: Hangzhou ICH Biofarm Co., Ltd
Tel: +undefined8613073685410
Email: sales@ichemie.com
Products Intro: Product Name:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:477600-74-1
Purity:99% Package:1kg;|5kg;|10kg
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:N-methyl-n-((3r,4r)-4-methylpiperidin-3-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:477600-74-1
Purity:98% Min. Package:1G;1KG;100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:477600-74-1
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 477600-74-1
CAS:477600-74-1
Purity:99% Package:25KG;5KG;1KG

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine manufacturers
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Basic information
Product Name:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonyms:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7HMethylpiperidin-3-yl)-7Hpyrrolo[ 2,3-d]pyriMidin-4-aMine;(3R,4R)-N,4-diMethyl-N-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}piperidin-3-aMine;7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-3-piperidinyl]-;N-Methyl-N-((3R,4R)-4-Methyl-piperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine;(3R,4R)-Methyl{(4-Methylpiperidin-3-yl)(7H-pyrrolo[2,3-d]pyriMidin-4-yl)}aMine;1H-Pyrrolo[2,3-d]pyriMidin-4-aMine,N-Methyl-N-[(3R,4R)-4-Methyl-3-piperidinyl]- (9CI);H-Pyrrolo[2,3-d]pyriMidin-4-aMine
CAS:477600-74-1
MF:C13H19N5
MW:245.32
EINECS:
Product Categories:
Mol File:477600-74-1.mol
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Structure
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Properties
Melting point 157 - 162°C
density 1?+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly, Heated)
form Solid
pka13.36±0.50(Predicted)
color White to Off-White
InChIInChI=1S/C13H19N5/c1-9-3-5-14-7-11(9)18(2)13-10-4-6-15-12(10)16-8-17-13/h4,6,8-9,11,14H,3,5,7H2,1-2H3,(H,15,16,17)/t9-,11+/m1/s1
InChIKeyXRIARWQZLGCQDM-KOLCDFICSA-N
SMILESC1=NC(N(C)[C@@H]2[C@H](C)CCNC2)=C2C=CNC2=N1
Safety Information
MSDS Information
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Usage And Synthesis
DescriptionN-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an important pharmaceutical intermediate that is a by-product of the preparation of tofacitinib. Tofacitinib belongs to a class of Janus kinase (JAK) inhibitors used in the treatment of rheumatoid arthritis and psoriatic arthritis.
UsesN-Methyl-N-((3S,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, is an intermediate in the synthesis of (3S,4R)-Tofacitinib (T528010), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Preparation Products And Raw materials
Raw materials1-Piperidinecarboxylic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, 1,1-dimethylethyl ester, (3R,4R)-
Tag:N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(477600-74-1) Related Product Information
Tofacitinib N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 3-Piperidinamine,4-methyl-1-(phenylmethyl)-,(3R,4R)-rel- methyl3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin -4-yl)amino)piperidin-1-yl)-3-oxopropanoate (3R,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Tofacitinib Impurity 6 (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanaMide 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Tofacitinib Impurity T