| Company Name: |
Hangzhou Taorui Biotechnology Co., Ltd
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| Tel: |
4000-360-990 15268198094 |
| Email: |
sales@torreybio.com |
| Products Intro: |
Product Name:Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-
CAS:2227482-41-7
Purity:95%+ Package:1g；5；10；
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ELOVL1-IN-1
CAS:2227482-41-7
Purity:98.55% Package:1mg/RMB 1650;5mg/RMB 3380;10mg/RMB 4970
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Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- manufacturers
- ELOVL1-IN-1
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- $136.00 / 1mg
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2025-04-29
- CAS:2227482-41-7
- Min. Order:
- Purity: 98.55%
- Supply Ability: 10g
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| | Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Basic information |
| Product Name: | Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- | | Synonyms: | ELOVL1-IN-1;1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide;ELOVL1-IN-27;Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-;chain,inhibit,adrenoleukodystrophy,Inhibitor,ELOVL1IN1,ALD,fatty,ELOVL-1-IN-1,acid,ELOVL1 IN 1,long;ELOVL1-27;ELOVL1-IN-1, 10 mM in DMSO | | CAS: | 2227482-41-7 | | MF: | C18H14F2N4O | | MW: | 340.33 | | EINECS: | | | Product Categories: | | | Mol File: | 2227482-41-7.mol | ![Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Structure](CAS/20210305/GIF/2227482-41-7.gif) |
| | Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Chemical Properties |
| Boiling point | 584.1±50.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: insol; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | | form | A crystalline solid | | pka | 12.79±0.20(Predicted) | | color | White to off-white |
| | Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Usage And Synthesis |
| Uses | ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1]. | | Biological Activity | ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1].
ELOVL1-IN-1 (compound 87) (1 nM-10 μM; 48 h) reduces the the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1].
ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1]. | | in vivo | ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1]. | | References | [1]. Charifson PS, et, al. 1,3-substitued pyrazole compounds useful for reduction of very long chain fatty acic levels. WO2018107056A1. |
| | Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Preparation Products And Raw materials |
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