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Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-

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Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:ELOVL1-IN-1；1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide
CAS:2227482-41-7
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Products Intro: Product Name:ELOVL1-IN-27
CAS:2227482-41-7
Purity:98% HPLC Package:1g
Company Name: Hangzhou Taorui Biotechnology Co., Ltd  
Tel: 4000-360-990 15268198094
Email: sales@torreybio.com
Products Intro: Product Name:Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-
CAS:2227482-41-7
Purity:95%+ Package:1g；5；10；
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:ELOVL1-IN-1;chain,inhibit,adrenoleukodystrophy,Inhibitor,ELOVL1IN1,ALD,fatty,ELOVL-1-IN-1,acid,ELOVL1 IN 1,long
CAS:2227482-41-7
Purity:98.55% Package:1 mg;10 mg;100 mg;200 mg;25 mg;5 mg;50 mg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:ELOVL1-27
CAS:2227482-41-7
Purity:98% Package:1mg;5mg;10mg
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Basic information
Product Name:Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-
Synonyms:ELOVL1-IN-1;1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide;ELOVL1-IN-27;Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-;chain,inhibit,adrenoleukodystrophy,Inhibitor,ELOVL1IN1,ALD,fatty,ELOVL-1-IN-1,acid,ELOVL1 IN 1,long;ELOVL1-27
CAS:2227482-41-7
MF:C18H14F2N4O
MW:340.33
EINECS:
Product Categories:
Mol File:2227482-41-7.mol
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Structure
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Chemical Properties
Boiling point 584.1±50.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: insol; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form A crystalline solid
pka12.79±0.20(Predicted)
Safety Information
MSDS Information
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Usage And Synthesis
Biological ActivityELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1]. ELOVL1-IN-1 (compound 87) (1 nM-10 μM; 48 h) reduces the the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1]. ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1].
References[1]. Charifson PS, et, al. 1,3-substitued pyrazole compounds useful for reduction of very long chain fatty acic levels. WO2018107056A1.
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Preparation Products And Raw materials
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