| Company Name: |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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| Tel: |
17702719238 18971495150; |
| Email: |
sales@sun-shinechem.com |
| Products Intro: |
Product Name:Zilurgisertib
CAS:2173389-57-4
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
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| Company Name: |
Chunchuang (Wuhan) Technology Co., Ltd
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| Tel: |
15727060112 |
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yutianchun2007@126.com |
| Products Intro: |
Product Name:3-Pyridinecarboxamide, 2-amino-N-(4-hydroxybicyclo[2.2.2]oct-1-yl)-5-[4-[(1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hex-1-yl]phenyl]-
CAS:2173389-57-4
Purity:99.5+HPLC Package:1mg;1g;10g;100g;1Kg;10Kg;100Kg;1T
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:INCB-000928
CAS:2173389-57-4
Purity:98.93% Package:1mg/RMB 1750;5mg/RMB 4390;10mg/RMB 6180
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:Zilurgisertib (INCB-000928, NBU-928)
CAS:2173389-57-4
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g
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| | 3-Pyridinecarboxamide, 2-amino-N-(4-hydroxybicyclo[2.2.2]oct-1-yl)-5-[4-[(1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hex-1-yl]phenyl]- Basic information |
| | 3-Pyridinecarboxamide, 2-amino-N-(4-hydroxybicyclo[2.2.2]oct-1-yl)-5-[4-[(1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hex-1-yl]phenyl]- Chemical Properties |
| Boiling point | 683.3±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | pka | 13.23±0.40(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | 3-Pyridinecarboxamide, 2-amino-N-(4-hydroxybicyclo[2.2.2]oct-1-yl)-5-[4-[(1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hex-1-yl]phenyl]- Usage And Synthesis |
| Uses | Zilurgisertib (INCB-000928; NBU-928) is a selective ALK2 inhibitor with an IC50 value of 15 nM. Zilurgisertib inhibits SMAD1/5 phosphorylation with an IC50 value of 63 nM. Zilurgisertib inhibits hepcidin production and improve anemia. Zilurgisertib can be used in melanoma research[1][2]. | | in vivo | Zilurgisertib can improve anemia in a mouse model of cancer-induced anemia, with increasing hemoglobin and red blood cell counts[2].
| | IC 50 | ALK2: 15 nM (IC50) | | References | [1] Li J, et al. Preparation of aminopyridine derivatives and their use as selective ALK-2 inhibitors. WO2018014829 A1.
[2] Stubbs M C, et al. ALK2 and JAK2 inhibition for improved treatment of anemia in myelofibrosis patients: Preclinical profile of an ALK2 inhibitor Zilurgisertib in combination with Ruxolitinib. Blood, 2023, 142: 1789. |
| | 3-Pyridinecarboxamide, 2-amino-N-(4-hydroxybicyclo[2.2.2]oct-1-yl)-5-[4-[(1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hex-1-yl]phenyl]- Preparation Products And Raw materials |
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