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| | 2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- Basic information |
| | 2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- Chemical Properties |
| Boiling point | 466.0±55.0 °C(Predicted) | | density | 1.342±0.06 g/cm3(Predicted) | | form | Solid | | pka | 9.81±0.10(Predicted) | | color | White to off-white |
| | 2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- Usage And Synthesis |
| Uses | MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research[1]. | | in vivo | MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice[1].
| Animal Model: | Hypoxic male C57BL/6J mice[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; once a day; 4 weeks | | Result: | Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition.
Decreased percentage of collagen fibers in pulmonary artery (PA).
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| | References | [1] HuijingHuang, et al. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol. 2019 Nov;76:105874. DOI:10.1016/j.intimp.2019.105874 |
| | 2(3H)-Benzoxazolone, 3-[(3-hydroxyphenyl)methyl]-5-methyl- Preparation Products And Raw materials |
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