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Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)-

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Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:CFT-2718
CAS:2154358-11-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10mg，more
Company Name: Shanghai Fine Biotech Co.，Ltd  
Tel: 18221172427
Email: sale@fine-biotech.com
Products Intro: Product Name:CFT-2718
CAS:2154358-11-7
Purity:98%HPLC Package:100mg;250mg;1g;5g,10g;25g;100g
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Basic information
Product Name:Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)-
Synonyms:Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)-;CFT-2718
CAS:2154358-11-7
MF:C22H17ClN6
MW:400.86
EINECS:
Product Categories:
Mol File:2154358-11-7.mol
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Structure
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Chemical Properties
Boiling point 688.0±65.0 °C(Predicted)
density 1.52±0.1 g/cm3(Predicted)
pka13.44±0.50(Predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Usage And Synthesis
UsesPROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
References[1] Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377. DOI:10.1158/1535-7163.MCT-20-0831
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- Preparation Products And Raw materials
Tag:Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)-(2154358-11-7) Related Product Information
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