多普吡地
| 中文名称 | 多普吡地 |
|---|---|
| 中文同义词 | 多普吡地;化合物 T11080 |
| 英文名称 | Dopropidil |
| 英文同义词 | Dopropidil;4205CERM;Pyrrolidine, 1-[1-[(2-methylpropoxy)methyl]-2-[[1-(1-propyn-1-yl)cyclohexyl]oxy]ethyl]- |
| CAS号 | 79700-61-1 |
| 分子式 | C20H35NO2 |
| 分子量 | 321.501 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 79700-61-1.mol |
| 结构式 |  |
多普吡地 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Calcium
Dopropidil is able to inhibit caffeine-induced contractions of rabbit renal arteries in a calcium-free medium (IC 50 =30.0 uM). Dopropidil inhibits norepinephnne (NE)-induced responses with IC 50 s of 2.7 and 29.8 uM, respectively. At 3 and 10 μM, Dopropidil significantly reduces the maximum increase in diastolic tension evoked by veratrine (IC 50 =2.8 μM).
Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min.