| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:TH-Z93
CAS:2260887-09-8
Purity:98% Package:5mg Remarks:S34156
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| | Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- Basic information |
| | Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- Chemical Properties |
| Boiling point | 693.4±65.0 °C(Predicted) | | density | 1.488±0.06 g/cm3(Predicted) | | form | Solid | | pka | 1.17±0.10(Predicted) | | color | White to off-white |
| | Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- Usage And Synthesis |
| Uses | TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1]. | | in vivo | TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].
| Animal Model: | B16-OVA cells (s.c.) xenograft mice model[1]. | | Dosage: | 20 μg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth and prolonged survival. |
| | References | [1] Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. DOI:10.1016/j.cell.2018.08.070 |
| | Phosphonic acid, P,P'-[[[4-(hexyloxy)-2-pyridinyl]amino]methylene]bis- Preparation Products And Raw materials |
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