| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:IMPDH2-IN-2
CAS:1434517-02-8
Purity:99.04% Package:1mg/RMB 993;5mg/RMB 2480;10mg/RMB 3970
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| | Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- Basic information |
| | Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- Chemical Properties |
| Boiling point | 648.5±55.0 °C(Predicted) | | density | 1.425±0.06 g/cm3(Predicted) | | pka | 11.29±0.43(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- Usage And Synthesis |
| Uses | IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1]. | | References | [1] Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756. DOI:10.1021/acs.jmedchem.7b01839 |
| | Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- Preparation Products And Raw materials |
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