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Taltirelin

Taltirelin Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:Taltirelin
CAS:103300-74-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Email: chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
Products Intro: CAS:103300-74-9
Company Name: Shaanxi Pioneer Biotech Co., Ltd .
Tel: 86-13259417953(Whatsapp)
Email: sales@pioneerbiotech.com
Products Intro: Product Name:Taltirelin Acetate
CAS:103300-74-9
Purity:0.99 Package:1g;25g;1kg;25kg;100kg
Company Name: Beijing Yibai Biotechnology Co., Ltd
Tel: 0086-182-6772-3597
Email: sales01@yibaibiotech.com
Products Intro: Product Name:Taltirelin
CAS:103300-74-9
Purity:99% HPLC Package:1g;10g;20g;50g;100g;200g;500g;1kg
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:Taltirelin
CAS:103300-74-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-48080

Lastest Price from Taltirelin manufacturers

  • Taltirelin
  • US $1.00 / KG
  • 2020-01-10
  • CAS:103300-74-9
  • Min. Order: 1g
  • Purity: 98%
  • Supply Ability: 200kgs
Taltirelin Basic information
Oral thyrotropin-releasing hormone
Product Name:Taltirelin
Synonyms:L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)-;L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI);TA 0910;(4S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide;Taltirelin;2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-;L-Prolinamide,(4S)-hexahydro-1-methyl-;(6S)-N-[(S)-1-[[(2S)-2-Carbamoylpyrrolizino]carbonyl]-2-(1H-imidazole-4-yl)ethyl]-2,4-dioxo-3-methylhexahydropyrimidine-6-carboxamide
CAS:103300-74-9
MF:C17H23N7O5
MW:405.41
EINECS:
Product Categories:Peptide;Chiral Reagents;Neurochemicals;Pharmaceuticals;Heterocycles;Intermediates & Fine Chemicals
Mol File:103300-74-9.mol
Taltirelin Structure
Taltirelin Chemical Properties
Melting point 72-75°
alpha 25D -13.6° (c = 1 in water)
density 1.447±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
pka9.32±0.40(Predicted)
Safety Information
MSDS Information
Taltirelin Usage And Synthesis
Oral thyrotropin-releasing hormoneTaltirelin is a pituitary hormone release stimulant,it is successfully developed by the Japanese Mitsubishi Tanabe Seiyaku Co. Ltd. ,its trade name is Taltirelin, it belongs to 3.1 class of new drugs of chemical drugs , currently it is used in clinical for improvement in patients with spinocerebellar degeneration,it is the most effective movement disorders drug.
Taltirelin is the world's first approved oral thyrotropin releasing hormone (TRH), in addition to having endocrine effects, it can also have effect on certain central nervous system (CNS) , including increasing locomotor activity, antagonistic reserpine-induced hypothermia, and antagonism of pentobarbital-induced sleep. The specie is developed by the Japanese Mitsubishi Tanabe Pharma Corporation in September 2000 for the first time in Japan, it is used to improve the ataxia in the patient's with spinocerebellar degeneration . Spinocerebellar ataxias (SCAs) formerly known as autosomal dominant ataxia, are a group of chronic degenerative diseases of the central nervous system with ataxia, dysmetria as the main clinical manifestations. In September 2000, thyrotropin releasing hormone (TRH)injection is the only drug for the treatment of such diseases. Taltirelin is the structural modification transform drug of TRH , pharmacological studies show that the product has strong and lasting multiple effects on CNS through brain TRH receptors . The excitatory effect of the product on CNS is 10 to 100 times stronger than TRH , the duration of action is about 8 times longer than TRH. The receptor affinity of the product is about 1/11 of TRH , and thus the endocrine effect of this product is weaker than TRH, but this product is more stable in vivo than TRH. In addition, the thyrotropin (TSH) release effect of the product is 1/6-1/11 of TRH , TSH release is regulated by a strong negative feedback system including thyroid hormone , it has a strong effect on the central nervous system, but while its hormone-like effect is small, and therefore it has fewer side effects. The main side effects are digestive reactions include vomiting, nausea and stomach discomfort. All adverse events are mild to moderate, they disappear during and (or) after treatment.
The above information is edited by the chemicalbook of Tian Ye.
DescriptionTaltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.
OriginatorTanabe Seiyaku (Japan)
UsesAnalog of thyrotropin releasing hormone TRH, with pronounced CNS activity. Used in the treatment of spinocerebellar degeneration.
Brand nameCeredist
Biological ActivitySynthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
Taltirelin Preparation Products And Raw materials
Tag:Taltirelin(103300-74-9) Related Product Information
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