茚托利辛
| 中文名称 | 茚托利辛 |
|---|---|
| 中文同义词 | 茚托利辛;化合物 T15586 |
| 英文名称 | Intoplicine |
| 英文同义词 | Intoplicine;11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole;7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl- |
| CAS号 | 125974-72-3 |
| 分子式 | C21H24N4O |
| 分子量 | 348.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 125974-72-3.mol |
| 结构式 |  |
茚托利辛 性质
| 熔点 | 216-218 °C |
|---|---|
| 沸点 | 635.5±55.0 °C(Predicted) |
| 密度 | 1.286±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.26±0.30(Predicted) |
Intoplicine 是 DNA 拓扑异构酶 I 和 II 抑制剂。
|
Topoisomerase I
|
Topoisomerase II
|
Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-101647 | Intoplicine | 1 mg | 3200元 | |
| 2024/01/25 | HY-101647 | 茚托利辛 Intoplicine | 125974-72-3 | 5mg | 8000元 |