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4-Chloro-4'-fluorobutyrophenone

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Company Name: ZHEJIANG JIUZHOU CHEM CO., LTD
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Products Intro: Product Name:4-Chloro-4'-fluorobutyrophenone
CAS:3874-54-2
Package:1KG
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Products Intro: Product Name:4-Chloro-4'-fluorobutyrophenone
CAS:3874-54-2
Purity:0.98 Package:1kg/;10kg/;50kg/;100kg/ Remarks:Gold product
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Products Intro: Product Name:4-Chloro-4'-fluorobutyrophenone
CAS:3874-54-2
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Products Intro: Product Name:4-Chloro-4'-fluorobutyrophenone
CAS:3874-54-2
Purity:99% Package:1kg;8USD|100kg;7USD|1000kg;6USD
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Products Intro: Product Name:4-Chloro-4'-fluorobutyrophenone
CAS:3874-54-2
Purity:0.99 Package:1kg

4-Chloro-4'-fluorobutyrophenone manufacturers
4-Chloro-4'-fluorobutyrophenone Basic information
Product Name:4-Chloro-4'-fluorobutyrophenone
Synonyms:3-CHLOROPROPYL4-FLUOROPHENYLKETONE/4-CHLORO-4''-FLUOROBUTYROPHENONE;1-Butanone, 4-chloro-1-(4-fluorophenyl)-;1-(4-Fluorophenyl)-4-chloro-1-butanone;γ-Chloro-4'-fluorobutyrophenone;ω-Chloro-4'-fluorobutyrophenone;Chloro-4'-fluorobutyrophe;4-Chloro-4'-fluorobu;4-chloro-4-fluorophenyl ketone
CAS:3874-54-2
MF:C10H10ClFO
MW:200.64
EINECS:223-395-3
Product Categories:API Intermediate;Aromatics;Miscellaneous Reagents;ketone;Fluorobenzene;C10;Carbonyl Compounds;Ketones;3874-54-2
Mol File:3874-54-2.mol
4-Chloro-4'-fluorobutyrophenone Structure
4-Chloro-4'-fluorobutyrophenone Chemical Properties
Melting point 5-6 °C
Boiling point 130-132 °C (0.97513 mmHg)
density 1.22 g/mL at 25 °C(lit.)
refractive index n20/D 1.5255(lit.)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Oil
color Slightly yellow-greenish clear
PH4.05 at 23.1℃ and 10g/L
Water Solubility 0.38 g/L (20 ºC)
BRN 608741
InChIKeyHXAOUYGZEOZTJO-UHFFFAOYSA-N
LogP2.84 at 30℃
CAS DataBase Reference3874-54-2(CAS DataBase Reference)
NIST Chemistry Reference1-Butanone, 4-chloro-1-(4-fluorophenyl)-(3874-54-2)
EPA Substance Registry System1-Butanone, 4-chloro-1-(4-fluorophenyl)- (3874-54-2)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 24/25-36-26
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 2914790090
MSDS Information
ProviderLanguage
4-Chloro-1-(4-fluorophenyl)-1-butanone English
SigmaAldrich English
ACROS English
ALFA English
4-Chloro-4'-fluorobutyrophenone Usage And Synthesis
Chemical Propertiesslightly yellow-greenish clear oil
Uses4-Chloro-4''-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.
SynthesisThe purified alkyne (5 mmol) was treated with a solution of HNTf2 (60-200 mol %) in 1,4-dioxane in apreheated oil bath at 100°C, under magnetic stirring, for 18-52 h, and the corresponding ketone was purified by column chromatography after cooling 4-Chloro-4'-fluorobutyrophenone. The reaction crude was purified by column chromatography using 20% AcOEt in n-hexane as an eluent. Isolated yield: 850 mg (85%). R f (20% AcOEt in n-hexane): 0.66. GC-MS (m/ z, M+? 200), major peaks found: 200 (1%), 164 (1%), 138 (43%), 123 (100%), 107 (10%). 1H NMR (δ, ppm; J, Hz): 8.03-7.97 (2C-H arom, mult), 7.17-7.09 (2C-H arom, mult), 3.68 (CH2, t, J = 6.2), 3.15 (CH2, t, J = 7.0), 2.22 (CH2, tt, J = 7.0, 6.2). 13C NMR (δ, ppm; J, Hz): 197.3 (C=O), 166.1 (C, d, J 1 C-F = 254.7), 133.2 (C, d, J 4 C-F = 4.3), 130.6 (2CH, d, J 3 C-F = 9.3), 115.9 (2CH, d, J 2 C-F = 22.2), 44.6 (CH2), 35.2 (CH2), 26.7 (CH2).
4-Chloro-4'-fluorobutyrophenone synthesis
4-Chloro-4'-fluorobutyrophenone Preparation Products And Raw materials
Preparation ProductsITI-722-->Cyclopropyl 4-fluorophenyl ketone-->Ciproxifan
Tag:4-Chloro-4'-fluorobutyrophenone(3874-54-2) Related Product Information
4-Fluorobenzaldehyde 2-Butanone oxime Epichlorohydrin 4-Methyl-2-pentanone Transfluthrin Florfenicol N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium HALOPERIDOL RELATED COMPOUND A (15 MG) (4,4'-BIS[(4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]-BU-TYROPHENONE) 3-CHLORO-4'-FLUOROPROPIOPHENONE 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(3-ethyl-4-fluorophenyl)-1-butanone Haloperidol EP Impurity E GUTXTARXLVFHDK-GIVHGBEGSA-N 4-[4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one Dechloro Haloperidol (Haloperidol Impurity B) Cyclopropyl 4-fluorophenyl ketone Haloperidol EP Impurity F 4-CHLORO-1-(2-FLUOROPHENYL)-1-OXOBUTANE 1-(4-FLUOROPHENYL)-4-HYDROXYBUTAN-1-ONE