- Photochlor Photochlor
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- $10.00 / 10g/Bag
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2021-12-14
- CAS:149402-51-7
- Min. Order: 10g
- Purity: 99
- Supply Ability: 100KG
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| 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid Basic information |
Product Name: | 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid | Synonyms: | Photochlor (HPPH);3-Phorbinepropanoic acid, 14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18 -tetramethyl-20-oxo-, (3S,4S)-;Sulcardine;14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid;2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a;(3S,4S)-14-Ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A;Photochlor (HTTP) | CAS: | 149402-51-7 | MF: | C39H48N4O4 | MW: | 636.82 | EINECS: | | Product Categories: | | Mol File: | 149402-51-7.mol | |
| 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid Chemical Properties |
Boiling point | 992.5±65.0 °C(Predicted) | density | 1.184 | storage temp. | Sealed in dry,Room Temperature | solubility | DMSO:3.0(Max Conc. mg/mL);4.7(Max Conc. mM) | form | A crystalline solid |
| 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid Usage And Synthesis |
Description | HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm. When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the tumor. HPPH, at a dose of 0.5 mg/kg, increases survival in a nude rat model of glioma. It works synergistically with gemcitabine in several pancreatic cancer cell lines to induce cell death. | Uses | Photochlor is an anticancer photodynamic therapy drug that triggers multiple drug release and tumor killing cells in mouse breast cancer xenograft. Also functions as a photochlor-mediated photodynamic therapy for non-small cellular lung cancer treatment in murine model. |
| 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid Preparation Products And Raw materials |
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